Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Lumps After Dog Vaccinations: Are They Normal? Our Vet Explains Why This Happens

close up dog getting vaccinated

Vaccines are the best way to protect your dog against serious diseases. Vets frequently vaccinate dogs for parvovirus, distemper virus, and hepatitis virus—this is often referred to as a “C3 vaccination.” Other vaccines are also available and may be recommended, depending on your dog and your whereabouts. These vaccinations include rabies, kennel cough, leptospirosis, and others.

You may have noticed a lump develop on your dog shortly after their vaccination. A common place to notice this lump is the back of the neck, as this is where most vets will give the injection. These lumps are generally a normal bodily reaction to the injection and will go away over time.

dogster paw divider

Are Post-Vaccination Lumps Normal?

Yes and no. They are not “normal” from a statistical perspective, as the vast majority of dogs will not develop lumps at the vaccination site. However, in the small number of dogs that do develop lumps, the lump is a normal immune response for that particular dog and is generally not cause for concern.

close up dog with skin lump
Image Credit: Todorean Gabriel, Shutterstock

What Does the Lump Look Like?

The lump is usually located in the “scruff” of the neck, or further down the back on the flank. This depends on where the injection was given.

It is usually a firm nodule that varies in size from a pea to a grape. Occasionally, it may be larger than this. The lump does not normally have discharge (fluid or pus) coming out of it. It may or may not cause pain when touched.

Why Do Dogs Get Lumps After a Vaccination?

Vaccinations work by stimulating the immune system. Essentially, your vet gives your dog a small and safe dose of a virus (or bacterium), which enables their immune system to create antibodies against the disease. When your dog then comes into contact with the disease, it has the antibodies stored in their immune memory-log, and can promptly use these to fight off infection.

A lump at the vaccination site is the result of the dog’s immune system at work. It has detected a substance that wouldn’t normally be there (the vaccine molecules) and sends immune cells there to clear up the perceived problem. The lump is an accumulation of immune cells, fluid, and possibly red blood cells.

hand holding syringe for rabies vaccine with a black dog in the background
Image Credit: Numstocker, Shutterstock

How Long Will the Lumps Stay?

Most lumps will start to shrink or even disappear, after about a week. Occasionally the lump will linger for longer and may last several months. While this may be a bit of a nuisance, a persistent lump is not necessarily a reason to be concerned.

When Should I Be Worried?

If you’ve noticed a lump that seemed to appear after a vaccination, it is worth getting your dog checked by a veterinarian. They can ensure that the lump is associated with the vaccination, and is not an unrelated problem. They can also check your dog’s health, to ensure they have not developed a fever, and if necessary, they can prescribe medications such as painkillers and antibiotics.

Most of the time, medications are not warranted, as the lumps are not painful, not infected, and will go away of their own accord.

If you’ve just noticed a lump at your dog’s vaccination site, given the above information, it may be reasonable to adopt a “watch and wait” approach. There are three main instances in which you should seek veterinary attention.

  • Your dog is showing signs of being unwell. If your dog is lethargic, has a reduced appetite, or has had vomiting and diarrhea, arrange a consultation with your veterinarian.
  • Your dog seems to be in pain when the lump is touched. No one wants their dog to be in pain; if the lump seems tender, arrange a visit to the vet, as pain-relief medications may be needed.
  • The lump is oozing or smells bad. This could be a sign that the lump has become infected.

If you’re concerned about your pet’s well-being, we recommend you contact a veterinarian.

Did you know you can talk to a vet online? Click on the image or button below to schedule a call: PangoVet_Mention-in-Content Savings V1


dogster face divider

A Brief Note on Cats

Cats can develop temporary, non-malignant lumps shortly after a vaccination, just as dogs can. However, some cats develop lumps at the site several months after their vaccination. These lumps can be a nasty, tumorous reaction known as a “post-vaccination sarcoma”. These are different from the lumps described in this article, and warrant prompt veterinary investigation.

dogster paw divider

Conclusion

If you’ve noticed a lump developing on your dog shortly after their vaccination, there is usually nothing to be concerned about. A common place for this lump is the back of the neck, as this is where the majority of vaccinations are administered. Thankfully, these lumps are typically a normal reaction to the injection and will go away on their own.


Featured Image Credit: fukume, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

How to Find a Mate for Your Dog (Offline & Online)

Finding a mate for your dog is something that many people want to do but may not know where to start. Not just...

11 Types of Dog Coats & How to Care for Them

Dogs come in all different shapes and sizes and with lots of different coats. While most people divide dogs into “shorthaired” and “longhaired,”...

Miniature Australian Shepherd: Info, Pictures, Traits & History

You’ve likely heard of the Australian Shepherd, but did you know that there was a miniature version? They are small to medium in...

How Much Does It Cost to Own a Poodle in 2025? Complete Pricing Guide

Poodles rank among the most popular dog breeds worldwide and are known for their allergy-friendly coats and intelligence. They’re also one of the...

More related

How to Train a Rottweiler to Be a Guard Dog (Step-by-Step Guide)

If you’ve just gotten a Rottweiler puppy, you may decide you want to train them to be a guard dog for your home....

Introducing PangoVet: Talk with a Veterinarian Online

Dogster is excited to announce the launch of our new vet telehealth service, PangoVet! The service is designed to give owners accessible and...

Bernese Mountain Dog Breed: Info, Pictures, Care & Traits

One of the Sennenhund-type dogs developed in the Swiss Alps, the Bernese Mountain Dog is a large breed that originated in Bern, Switzerland....

Blue Nose Pitbull: Info, Pictures, Care Guide & More

Almost everyone has heard of the Pitbull, but have you ever heard of the Blue Nose Pitbull? If not, you’ve come to the...

Keep reading

Can Dogs Eat Pork? Vet-Approved Nutrition Facts & FAQ

There is always a time for pork, whether it’s crispy bacon to accompany your waffles, pork sausages for lunch, or a pork roast with all the trimmings for a special occasion. There are many opportunities where pork can get your...

Can Dogs Eat Pork

Freeze-Dried vs. Dehydrated Dog Food 2025 Comparison: Pros & Cons

Many dog owners who are trying to feed their canines healthier foods choose either freeze-dried foods or dehydrated foods. On the shelf, both of these foods can look reasonably similar. However, they are quite different. Luckily, the differences aren’t all...

Dogster_Freeze-Dried vs. Dehydrated Dog Food

6 Foods High In Thiamine for Dogs: Vet-Approved Vitamin B1 Sources

Thiamine, also known as vitamin B1, is an essential nutrient for dogs and humans. Dogs require it for carbohydrate metabolism, optimal growth, and efficient nerve function. Because dogs’ bodies don’t store the nutrient, they need to obtain it through what...

French bulldog eating from a bowl

Can Dogs Eat Bamboo Shoots? Vet-Reviewed Facts & FAQ

Bamboo shoots are a popular vegetable in many Asian countries and have been enjoyed as a dietary staple for centuries. If you’re cooking with bamboo shoots in your home and your dog steals a bite, or you’re just wondering if...

Can Dogs Eat_bamboo shoots

Can Dog Food Cause Urinary Incontinence? Vet Approved Facts & FAQ

Witnessing a dog suffer from urinary incontinence is difficult for a pet owner. Knowing that your pet is dealing with an issue, that in some cases isn’t treatable, is heart-wrenching. While a trip to the vet is necessary when this...

Dog Pee Rug

Can You Return Dog Food to Petco? 2025 Guide & FAQ

Whether you are considering trying out a new dog food from Petco, or you’ve recently had an issue with food you purchased, you may be wondering if the store will accept returns. Dog food can get quite expensive, and if...

Petco pet shop

Can Dogs Eat Guava? Vet-Verified Nutrition Facts & FAQ

While not every kind of fruit is suitable for dogs, some are safe to feed in moderation and can even offer a nutritional boost. Guava is a tropical fruit from the Myrtle family that grows on trees. Guava is a...

Can Dogs Eat Guava

Is Spicy Food Bad for Dogs? Vet-Verified Nutrition Facts & Advice

While dogs can enjoy many of the same foods as humans, they should not eat spicy food. Although most spicy food isn’t toxic to dogs, it can still lead to negative consequences. So, it’s best to avoid giving any to...

spicy grilled chicken