Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Lumps After Dog Vaccinations: Are They Normal? Our Vet Explains Why This Happens

close up dog getting vaccinated

Vaccines are the best way to protect your dog against serious diseases. Vets frequently vaccinate dogs for parvovirus, distemper virus, and hepatitis virus—this is often referred to as a “C3 vaccination.” Other vaccines are also available and may be recommended, depending on your dog and your whereabouts. These vaccinations include rabies, kennel cough, leptospirosis, and others.

You may have noticed a lump develop on your dog shortly after their vaccination. A common place to notice this lump is the back of the neck, as this is where most vets will give the injection. These lumps are generally a normal bodily reaction to the injection and will go away over time.

dogster paw divider

Are Post-Vaccination Lumps Normal?

Yes and no. They are not “normal” from a statistical perspective, as the vast majority of dogs will not develop lumps at the vaccination site. However, in the small number of dogs that do develop lumps, the lump is a normal immune response for that particular dog and is generally not cause for concern.

close up dog with skin lump
Image Credit: Todorean Gabriel, Shutterstock

What Does the Lump Look Like?

The lump is usually located in the “scruff” of the neck, or further down the back on the flank. This depends on where the injection was given.

It is usually a firm nodule that varies in size from a pea to a grape. Occasionally, it may be larger than this. The lump does not normally have discharge (fluid or pus) coming out of it. It may or may not cause pain when touched.

Why Do Dogs Get Lumps After a Vaccination?

Vaccinations work by stimulating the immune system. Essentially, your vet gives your dog a small and safe dose of a virus (or bacterium), which enables their immune system to create antibodies against the disease. When your dog then comes into contact with the disease, it has the antibodies stored in their immune memory-log, and can promptly use these to fight off infection.

A lump at the vaccination site is the result of the dog’s immune system at work. It has detected a substance that wouldn’t normally be there (the vaccine molecules) and sends immune cells there to clear up the perceived problem. The lump is an accumulation of immune cells, fluid, and possibly red blood cells.

hand holding syringe for rabies vaccine with a black dog in the background
Image Credit: Numstocker, Shutterstock

How Long Will the Lumps Stay?

Most lumps will start to shrink or even disappear, after about a week. Occasionally the lump will linger for longer and may last several months. While this may be a bit of a nuisance, a persistent lump is not necessarily a reason to be concerned.

When Should I Be Worried?

If you’ve noticed a lump that seemed to appear after a vaccination, it is worth getting your dog checked by a veterinarian. They can ensure that the lump is associated with the vaccination, and is not an unrelated problem. They can also check your dog’s health, to ensure they have not developed a fever, and if necessary, they can prescribe medications such as painkillers and antibiotics.

Most of the time, medications are not warranted, as the lumps are not painful, not infected, and will go away of their own accord.

If you’ve just noticed a lump at your dog’s vaccination site, given the above information, it may be reasonable to adopt a “watch and wait” approach. There are three main instances in which you should seek veterinary attention.

  • Your dog is showing signs of being unwell. If your dog is lethargic, has a reduced appetite, or has had vomiting and diarrhea, arrange a consultation with your veterinarian.
  • Your dog seems to be in pain when the lump is touched. No one wants their dog to be in pain; if the lump seems tender, arrange a visit to the vet, as pain-relief medications may be needed.
  • The lump is oozing or smells bad. This could be a sign that the lump has become infected.

If you’re concerned about your pet’s well-being, we recommend you contact a veterinarian.

Did you know you can talk to a vet online? Click on the image or button below to schedule a call: PangoVet_Mention-in-Content Savings V1


dogster face divider

A Brief Note on Cats

Cats can develop temporary, non-malignant lumps shortly after a vaccination, just as dogs can. However, some cats develop lumps at the site several months after their vaccination. These lumps can be a nasty, tumorous reaction known as a “post-vaccination sarcoma”. These are different from the lumps described in this article, and warrant prompt veterinary investigation.

dogster paw divider

Conclusion

If you’ve noticed a lump developing on your dog shortly after their vaccination, there is usually nothing to be concerned about. A common place for this lump is the back of the neck, as this is where the majority of vaccinations are administered. Thankfully, these lumps are typically a normal reaction to the injection and will go away on their own.


Featured Image Credit: fukume, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Mantle Great Dane: Info, Pictures, Origin & History

Mantle Great Danes represent one of the flashiest color patterns of an already hard-to-miss dog breed. Sporting a black “blanket” or mantle across...

Why Do Dogs Howl When You Howl? 5 Common Reasons

Dogs make a lot of interesting vocalizations, but none are quite as loud or jarring as the howl. Most dog owners know that...

Labrador Retriever Puppies for Sale in Kansas: 2025 Breeders List

With Labrador Retrievers as popular in Kansas as they are throughout the United States, Lab breeders can be found all throughout the state....

What Breed of Dog Is Fang in Harry Potter? Cinema Dogs Presented

If you’re wondering which dog breed Fang from Harry Potter is, fear not! We’ve got your back! We’ll give you all the information...

More related

15 Superfoods For Dogs: Our Vet Lists Top Foods & Their Benefits

Whether you’re a health fanatic or someone looking to add excellent nutrition to your dog’s diet, you might be wondering about superfoods that...

My Puppy Hates the Crate: How to Get Them to Love It (Vet-Approved Tips)

Crate training is an important part of welcoming a pup of any age into your home. Crates can be useful for training puppies...

How Fast Can a German Shepherd Run? Average & Max Speed

Four-legged animals and birds have an advantage over humans. Many can outrun us, even if it’s just for short jaunts. Because of these...

Cerberus: The Hellhound of Greek Mythology

When you think of Greek mythology, you’re likely flooded with images of unseen creatures, masculine gods, and fearsome goddesses. There are several allegories,...

Keep reading

Can Dogs Eat Hot Sauce? Vet-Verified Health Facts

Some people like their food to be extra spicy, with hot sauces being a $1.65 billion market in the United States. Of course, not everyone likes the heat. That includes your dog. Wild or domestic canines don’t encounter this taste...

Can Dogs Eat Hot Sauce

10 Best Dog Foods for Chihuahuas in 2025 – Reviews & Top Picks

Choosing food for Chihuahuas is challenging because they are so small! The average dog food simply won’t work for them, as the kibble will often be much too big. Instead, only the smallest kibble size will do, or you’ll need...

close up Chihuahua eating

Members Mark vs Kirkland Dog Food (2025 Comparison): Pros, Cons, and What to Choose

It is no secret that Americans love their dogs. In fact, according to the American Pet Products Association, 68% of US households include a pet—and that number is only growing. With so many people making pets a part of their...

Dogster_Dog Food Members Mark VS Kirkland

Can Dogs Eat Provolone Cheese? Vet-Verified Nutrition Facts & FAQ

Many foods aren’t necessarily toxic or poisonous to dogs, but they’re still not very good for them to eat. Cheese is one of those foods that doesn’t contain any toxic ingredients for dogs, but it’s not something that you should...

Can Dogs Eat Provolone Cheese

Can Dogs Eat Salsa? Vet Approved Facts & FAQs

Salsa is a spicy relish composed of tomatoes, peppers, herbs, limes, onions, and spices. It’s usually paired with tortilla chips as an appetizer, but it can also be used as a topping or filling for tacos, enchiladas, or burritos. Salsa...

Can Dogs Eat Salsa

10 Best Foods for English Bulldog Puppies in 2025 – Reviews & Top Picks

Full of charm, humor, and personality, English Bulldogs are among the most popular and well-known dog breeds in the world. All puppies are hard to resist, but the wrinkly skin and smooshed noses of baby Bulldogs make them even more...

feeding english bulldog puppy

What Do Rottweilers Eat? Vet-Approved Feeding Guide

Rottweilers are big dogs with big appetites to match, so it’s essential to feed them appropriately to ensure they’re getting the nutrients they need to thrive. However, the number of dog food products available can make choosing the right diet...

rottweiler dog sitting next to an empty bowl

Can Dogs Eat Bok Choy? Vet-Verified Health Facts & FAQ

Most dogs love it when you offer them something different from their usual diet, and what could be better than healthy treats like veggies? But certain seemingly harmless vegetables can pose health risks to your beloved dog. For example, dogs...

Can Dogs Eat_bok choy