Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Histoplasmosis in Dogs: Signs, Causes, and Treatment Options (Vet Answer)

Written by: Dr. Stacie Grannum DVM (Veterinarian)

Last Updated on April 3, 2024 by Dogster Team

Histoplasmosis in Dogs: Signs, Causes, and Treatment Options (Vet Answer)


Dr. Stacie Grannum  Photo


Dr. Stacie Grannum

DVM (Veterinarian)

The information is current and up-to-date in accordance with the latest veterinarian research.

Learn more »

Dogs can inhale or ingest fungal spores from the environment and acquire a fungal infection in their lungs, intestinal tract, or systemically in several organs and tissues. One such fungal infection is histoplasmosis. Diagnosis of this disease involves cytology and/or histopathology evaluation, and treatment may involve a prolonged and expensive course of antifungal therapy.

Dogster_Website dividers_v1_Jan 18 2024-03

What Is Histoplasmosis?

Histoplasmosis is a fungal infection caused by the soil fungus, Histoplasma capsulatum. This fungus thrives in moist and warm conditions, especially in soil containing bird or bat droppings. In the United States, H. capsulatum is commonly found along the Mississippi, Missouri, and Ohio River valleys but can be found all throughout the world. Histoplasmosis can occur in humans and animals, with cats and dogs being the most commonly affected.

A dog sniffing a scent
Image Credit: Pawtraits, Shutterstock

What Are the Signs of Histoplasmosis in Dogs?

Histoplasmosis in dogs can produce signs that are non-specific and variable 2 to 3 weeks after infection.

Common signs may include:
  • Fever
  • Lethargy
  • Weight loss
  • Inappetence
  • Labored breathing
  • Coughing
  • Diarrhea
  • Black or tarry stools
  • Straining to defecate
  • Enlarged lymph nodes, liver, or spleen
  • Ulcerations in the throat or along the gastrointestinal tract
  • Draining skin lesions
  • Eye infections
  • Joint pain and lameness

What Are the Causes of Histoplasmosis in Dogs?

Histoplasmosis is most commonly acquired by breathing in the spores of the fungus, which travel into the lower airways of the lungs, then multiply and cause infection. Spores can also cause infection in the intestinal tract by entering through the mouth. The infection may remain in the lungs or intestines, but it can also cause a systemic infection by spreading through the bloodstream to other parts of the body, such as the lymph nodes, spleen, liver, eyes, and skin.

Dogs that are exposed to high levels of fungal spores for an extended period of time may have a greater chance of contracting the disease. Young, large-breed hunting dogs may be more at risk. Pointers, Weimaraners, and Brittany Spaniels were found to have an increased risk in one study, but this is likely due to their hunting behavior habits rather than their breed specifically.

male silver weimaraner dog
Image Credit: Dmitry Veryovkin, Shutterstock

How Will a Veterinarian Diagnose Histoplasmosis?

Your veterinarian will gather your dog’s complete medical history, including any recent travel in the last month or two that may have exposed your dog to fungal spores. The vet will complete a thorough physical examination of your dog and may recommend testing, such as blood work, urinalysis, X-rays, and ultrasound, to help determine the cause of your dog’s signs.

If your veterinarian is suspicious of a histoplasmosis infection, they may recommend cytology to aspirate a fluid sample from your dog’s lymph node or collect a small sample of draining fluid from an open wound to examine the cells under a microscope. Histopathology may also be needed to confirm a diagnosis by taking a biopsy of a tissue sample and having a pathologist examine it.

How Do I Care for a Dog With Histoplasmosis?

Histoplasmosis may be treated with antifungal medications.

Commonly prescribed treatments include:
  • Fluconazole
    • Diflucan®
  • Itraconazole
    • Itrafungol®
    • Sporanox®
It is important to note that antifungal therapy may be needed for 6 months or longer to effectively treat the disease. Not all dogs will recover, especially those with advanced disease or poor body condition. Dogs with a systemic infection or an infection present in the eyes or nervous system may also be more difficult to treat than those with a localized lung infection. Hospitalization may be needed for dogs in poor condition. Follow-up X-rays, bloodwork, and urine testing may be required to track treatment progress.

vet performing blood test on dog
Image Credit: thirawatana phaisalratana, Shutterstock

Dogster_Website dividers_v1_Jan 18 2024-03

Frequently Asked Questions

Can I Contract Histoplasmosis From My Dog?

It’s not likely, but you should still maintain strict hygiene practices, especially if draining wounds are present. Wear protective gloves, and wash your hands with soap and water after handling an infected pet. If anyone in your household is immunocompromised, such as young children, an elderly parent, or someone undergoing chemotherapy, you should discuss safety precautions with your primary care doctor.

What Treatment Options Are Available for a Dog With Histoplasmosis?

Treatment may include antifungal therapy, such as fluconazole or itraconazole. Pain medication may also be administered. Some dogs may need to be hospitalized or receive supportive care, especially if they have difficulty breathing or are not eating.

dog not eating its food
Image Credit: Daria Lixovetckay, Shutterstock

How Long Do I Need to Treat My Dog for Histoplasmosis?

Recovery is usually prolonged. It may take 6 months or longer to successfully eliminate the fungus.

How Can I Prevent My Dog From Contracting Histoplasmosis?

One of the best preventive measures is to prevent your dog from eating bird or bat droppings. Keep them away from caves, bird coops, and other places where birds and bats congregate. Rotting wood may also be a source of fungal infection. Be mindful of places where the fungus is especially prevalent.


Histoplasmosis is a fungal infection that can occur in dogs. It is caused by fungal spores that are either inhaled or ingested from the soil and cause infection in the lungs, intestinal tract, or systemically. Signs may be non-specific. A diagnosis is confirmed through cytology or histopathology. Treatment may consist of antifungal medications.

Not all histoplasmosis cases will be treated successfully, however, and dogs with advanced disease or poor body condition may have a poorer prognosis.

Featured Image Credit: SeventyFour, Shutterstock

Get Dogster in your inbox!

Stay informed! Get tips and exclusive deals.
Dogster Editors Choice Badge
Shopping Cart


© Pangolia Pte. Ltd. All rights reserved.