Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Can Dogs Catch Parvo Twice? Our Vet Explains the Signs, Treatments & Prevention

Beagle dog lying down waiting for owner with sad face

Parvo is one of the most dreaded diseases among dog owners, and for a good reason. However, if your dog has survived parvovirus, can they be infected again? The good news is that it’s very unlikely for your dog to catch parvo twice, but it depends on their immunity to the virus.

Vaccinations are still recommended to boost your dog’s immunity to parvo and other diseases. Dogs that have recovered from parvovirus are also more likely to have chronic gastrointestinal problems later in life, so if your dog has vomiting or diarrhea after recovery, it may be related to but not directly caused by parvovirus infection.

divider dog paws 2 oct 2024

What Is Parvo?

During the ’70s, a worldwide canine pandemic occurred; thousands of dogs died from parvovirus or “parvo.” Parvo is a contagious and deadly disease caused by strains Canine Parvovirus Type 2 (CPV-2) .

Parvovirus causes severe gastrointestinal signs and low white cell counts in infected dogs, which can lead to their death from sepsis and other complications. Young puppies under 3 months old can develop myocarditis (inflammation of the heart muscle) from the virus. Studies have shown survival rates between 10% and 91%. Due to a mutation, the virus is thought to have originated from a feline virus.

mixed breed puppy with parvovirosis at the veterinary clinic
Image Credit: Todorean-Gabriel, Shutterstock

Canines More Susceptible to Parvovirus

Young puppies and some dog breeds are more susceptible to parvovirus.1 Wild canines like foxes, wolves, and coyotes can be infected with parvovirus and, unfortunately, act as reservoirs for the disease that can be passed onto pet dogs. The virus is transmitted when dogs ingest it, which is shed in the droppings of infected dogs.

Duration of Contagion

The shedding in feces represents a contagious period that lasts from before clinical signs start until weeks after the signs resolve. Under the right conditions, the virus can live outside the body for many months. Since it is not killed easily, it can be tracked in on shoes or paws; your dog does not need direct contact with an infected dog to contract parvovirus.

Following ingestion, parvovirus enters white blood cells, which carry it to the bone marrow, intestinal lining, and other organs. It uses the rapidly dividing cells of the bone marrow and intestinal lining to replicate and destroy the cells afterward.

puppy lies on the cage with an IV line inserted into his front leg due to Canine parvovirus
Image Credit: MDV Edwards, Shutterstock

Signs of Parvo

Since the compromised intestinal lining cannot exchange nutrients between the body and gut or protect the body from bacteria, dogs show signs like severe vomiting, diarrhea, lack of appetite, and lethargy. Your vet may note abdominal pain, dehydration, shock, or changes in body temperature.

Since the bone marrow produces the white blood cells responsible for fighting infection, the dog’s natural defenses are weakened, allowing the virus to spread much more easily. Dogs that die generally succumb within a few days.

If you suspect your pet is suffering from parvo, you should contact your vet directly for an assessment. They can provide you with more information and a care plan.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the personalized advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content Savings V1

Parvo Treatments

Traditionally, treatment for parvovirus can include broad-spectrum antibiotics and supportive care targeted at reducing dehydration, malnutrition, nausea, pain, and electrolyte imbalances. More advanced therapies like plasma transfusions and antiviral medication can be helpful.

A new treatment for parvovirus called Canine Parvovirus Monoclonal Antibody is showing promising results.2 One study showed a 100% survival rate in treated dogs, compared to 43% in the control group.3

labrador retriever puppy getting vaccinated
Image Credit: Olya Maximenko, Shutterstock

divider dog paws 2 oct 2024

How Immunity Works

A dog’s biggest defense against parvovirus comes from their immune system. When pups are born, their mother produces a special milk called colostrum, which contains some of her antibodies. So, if mom has been vaccinated against parvovirus, she passes some immunity onto her pups to protect them early in life. This is called passive immunity.

Passive Immunity

One study showed that higher levels of antibodies give greater protection against parvovirus.4 Unfortunately, passive immunity dwindles over time, with antibody levels halving every 10 days, and pups must then rely on their own immune systems to fight the virus.

red Labrador retriever puppy lying on floor with sad face
Image Credit: Stacey Welu, Shutterstock

Adaptive Immunity

Adaptive immunity is an immune response targeting specific antigens, like those found in parvovirus. The dog’s white blood cells attack the virus, which leads to the immune system remembering how to fight the infection in the future. That is why dogs that have contracted parvovirus are unlikely to succumb to the infection a second time.

Immunity after parvovirus infection could last around 1-3 years. However, some vets assume lifelong immunity is achieved because of the low re-infection rate. As this is an unproven theory, we recommend other measures to protect your dog from parvovirus.

The good news is that your dog doesn’t have to contract parvovirus to develop adaptive immunity. Vaccinations contain weakened or killed versions of the virus, so your dog’s immune system can be exposed to the virus with very few risks to their health. The vaccines protect against multiple prevalent strains of parvovirus.

Parvo Vaccinations

Following your vet’s vaccination schedule when immunizing your puppy against parvovirus is vital. Remember those antibodies from the mother? Well, they can actually kill the vaccinations, rendering them ineffective. In some cases, the maternal antibodies kill the vaccine but leave the puppy open to contracting parvovirus; this “vulnerable period” lasts about a week and is different for every dog.

That is why a series of three to four puppy vaccinations, 2 to 4 weeks apart, are generally recommended, depending on your pup’s age and history. After the puppy vaccinations, a booster is given annually and, eventually, every 1-3 years. The DAPP vaccine protects not only against parvovirus but also canine distemper virus (CDV), canine adenovirus type 1 and 2 (CAV1 and CAV2), and canine parainfluenza virus (CPiV).

If you are unsure about vaccinating your dog for medical reasons, like previous vaccine reactions, we recommend a titer test, which can determine your dog’s level of antibodies against parvovirus. Vaccination is the most effective prevention against parvovirus, but it’s not a 100% guarantee. “Vaccine failures” occasionally occur due to new strains or infections in the vulnerable period.

Cute Labrador puppy getting a vaccine
Image Credit: ARVD73, Shutterstock

Long-Term Effects of Parvo

Dogs may develop chronic gastrointestinal problems after recovering from parvovirus, and the risk increases with the severity of the initial disease. One study found that around 40% of dogs that survived parvovirus developed chronic gastrointestinal signs, compared to 10% of other dogs.

Researchers don’t yet know what triggers these dogs’ chronic signs, but disturbances in the gut microbiome and inflammatory bowel disease have been suggested as possible causes. If your dog is struggling with vomiting, diarrhea, or any other signs, we recommend a vet visit to investigate the many possible causes and make a treatment plan.

divider dog paws 2 oct 2024

How to Prevent Parvovirus

Since passive and adaptive immunity to parvovirus are not foolproof solutions, we want you to keep your dog safe by taking safety measures to protect them from parvo.

We recommend that you:
  • Vaccinate all your dogs against parvovirus according to your vet’s recommendations.
  • Talk to your vet about the prevalence of parvovirus in your area and when you should allow your puppy to be out in public.
  • Quarantine your dog during and after a parvovirus infection to avoid spreading the virus.
  • Be aware that parvovirus can stay in the environment for months. If you have had a parvovirus-positive dog in your home, you should not take in unvaccinated animals or puppies in a potentially vulnerable period.
  • Once your pup has fully recovered from parvovirus, bathe them thoroughly to reduce the amount of virus on their fur.
  • Choose pet-care services that require up-to-date vaccinations, isolate sick dogs, and disinfect the premises.
  • Keep your dog away from other dog’s feces and pick up after your dog.
  • Change your clothes and wash your hands after being in contact with a parvovirus-infected dog or potentially infected areas.
  • Disinfect indoor areas and items with a solution containing 1 part bleach and 30 parts water, e.g., 133 ml bleach in 4 liters of water. Most other household disinfectants will not kill parvovirus.
  • For infected grassy areas, water the lawn regularly to dilute the virus. However, this will not kill all the virus particles on your lawn. Ask your vet about when the outdoor area will be considered safe again, but know that freezing preserves the virus, and shaded areas can harbor the live virus for around 7 months.

divider dog paws 2 oct 2024

Conclusion

A second infection with parvovirus is very unlikely but theoretically possible. Since parvo is so serious, we recommend a multimodal approach to protecting your dog. Regular vaccinations are the most important prevention tactic and should be used to keep your dog safe not only from parvovirus but also from other diseases.

You can also take protective measures against parvovirus. If your dog is showing gastrointestinal signs again after parvo, visit a vet who can make a treatment plan to help your dog.


Featured Image Credit: N_T, Shutterstock

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

How to Get a Psychiatric Service Dog: 6 Vet-Approved Tips

Service dogs play a very important role in the lives of their handlers. They aid people with both physical and mental disabilities and...

Rhodesian Ridgeback Beagle Mix: Info, Pictures, Temperament & Traits

If you’re in search of a loyal, intelligent, and strikingly beautiful companion, look no further than the Rhodesian Ridgeback Beagle. This unique hybrid...

Assistance Dog Day 2025: When & What It Is

Assistance Dog Day is an important holiday devoted to spreading awareness about how dogs improve the lives of countless people living with mobility-limiting...

8 Best Outdoor Dog Beds in 2025 – Reviews & Top Picks

Dogs like to hang around outside on sunny days and often enjoy the outdoors in cold weather as well, so it’s a good...

More related

Long-Haired Dalmatian: Info, Pictures, Origin & Characteristics

The Dalmatian is a white dog with black or brown spots and is the unofficial mascot for firefighters in the US.1 However, it’s...

Do You Need a License to Breed Dogs? Vet-Reviewed Ethics & Legal Info

Breeding is a hot topic among dog lovers everywhere, especially backyard breeding. Pet parents want to be sure the dogs they’re purchasing are...

10 Dog-Friendly Trails in Hocking Hills State Park in 2025 (With Pictures)

Hocking Hills is home to many stunning trails and parks in Ohio, and most are dog-friendly. Hikers and their canine companions can marvel...

10 Health Benefits of Owning a Pet: Vet-Approved Facts

Whether you have a cat, dog, bird, gerbil, chameleon, or hedgehog as a pet, you already know all the joy and comfort that...

Keep reading

15 Holiday Foods That Are Bad for Dogs (Vet Reviewed)

Holidays are a lot of fun, no matter what holiday is being celebrated. There’s family, friends, decorations, and most importantly, food! Some of the most delicious foods we eat all year are holiday foods, so you might be tempted to...

top view of golden retriever near family holding glasses of white wine during thanksgiving dinner

Can Dogs Eat Mexican Rice? Vet-Verified Facts & Tips

It’s not unusual for people to search for ideas on new things for their dogs to eat. Pet owners want their dogs to enjoy new things from time to time instead of routine dog food. Considering that rice is often...

Can Dogs Eat Mexican Rice

6 Best Air-Dried Dog Foods in 2025 – Reviews & Top Picks

Air-dried dog food hasn’t been around on the market for all that long, but it deserves more attention than it’s been given. Often over-shadowed by freeze-dried or dehydrated dog food, air-dried dog food is often overlooked but can stand its...

miniature schnauzer dog eating on the sofa

10 Best Senior Dog Foods for Weight Loss in 2025 – Reviews & Top Picks

As dogs age, they become less active, and their bodies are less able to burn off calories. Therefore, senior dog food often has fewer calories than adult dog food, but that isn’t always the case. When shopping for the best...

Senior dog eating dog food

Can Dogs Eat Tomatoes? Health & Nutrition Facts

Whether eaten raw or cooked in a delicious sauce, tomatoes are a staple of many human diets. If you’re tempted to slip your dog a slice, you’ll first want to determine whether dogs can safely eat tomatoes. Ripe tomatoes are...

Can Dogs Eat Tomatoes

4Health Dog Food Review 2025: Pros, Cons, Recalls & FAQ

If you don’t have a Tractor Supply Co. in your area, you might not have heard of their private label dog food brand, 4Health. The brand offers limited ingredient foods that include real meat and veggies in both grain-free and...

Dogster_4Health Dog Food Review

Emergency Dog Food: What To Keep In a Survival Kit

Disasters are unpredictable, and the safety of our beloved canine companions is paramount during these critical times. Thankfully, preparedness goes a long way in ensuring the well-being of our furry friends. So, if you’re wondering what to put in a...

pug dog eating from feeding bowl

Redbarn Dog Food Review 2025: My Food-Sensitive Dog Tries the Most Popular Recipes

It was back in the 1990s when two close friends decided that they wanted to provide high-quality dog food to pets around the nation. Redbarn dog food had its first success with their premium rolled dog food and soon decided...

DOG_SAPR_Redbarn Dog Food