Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Allergy Medicine for Diabetic Dogs: What Is Safe for Them to Take (Vet Answer)

Owner giving medicine in a pill to his dog

Your pup is itchy, and it’s keeping you up—no wonder you’re interested in allergy medication for your dog. The question is, what kind of allergy medication can your dog take because it’s diabetic? Let’s look at some allergy medications and see what your furry family member can take to help you both get some sleep tonight.

divider dog faces oct 2024

What Is an Antihistamine?

An antihistamine is an allergy medication that helps block the effects of histamine on the body. These medications come in many forms and tend to be effective at controlling many allergy signs and symptoms.

Unfortunately, in dogs, signs of allergies aren’t just caused by histamine; they’re also caused by inflammatory cells like cytokines. Most dogs don’t have itchy, watery eyes as part of their allergy manifestation; they tend to develop ear infections and lick their paws. As such, many dogs are not well controlled by antihistamines. One study showed that only 27% of dogs responded well to antihistamines1.

The most commonly used antihistamines in dogs are human medications that veterinarians use off-label.

Some of these that are safe for diabetic dogs include:
  • Diphenhydramine (Benadryl)
  • Cetirizine (Zyrtec)
  • Loratadine (Claritin)
  • Chlorpheniramine (Chlor-Trimeton)
  • Hydroxyzine (Atarax)

A veterinarian might recommend a newer medication to control your dog’s allergies that isn’t an antihistamine.

These medicines include:
  • Apoquel
  • Cytopoint
  • Atopica

Many dogs need a multipronged approach to treat allergies. These treatments can include topical products, such as shampoos. Many veterinarians recommend omega-3 fatty acid products, such as Welactin, to help decrease inflammation and itchiness.

woman and labrador dog consulting with the vet
Image Credit: SeventyFour, Shutterstock

divider dog faces oct 2024

How Are Allergy Medications Given to Dogs?

Most allergy medications, especially antihistamines, are given to dogs in tablet form. These are generally unflavored tablets, but some are available in a liquid formulation.

Apoquel is only available as a tablet, but the company has made a chewable tablet to help encourage dogs to take the medication. Cytopoint is an injection that the veterinarian administers every 4 to 8 weeks. Atopica is usually used in a capsule formulation, but some small dogs can utilize the liquid cat version.

Antihistamines do not usually have interactions with insulin and can typically be given at similar times. Atopica and Cytopoint manufacturers do not report any interactions with insulin treatment either, but it is best to follow the veterinarian’s guidelines to ensure the safest and most effective treatment plan for your dog.

Talk to a veterinarian about whether an antihistamine or other allergy medication might be effective for your dog’s allergy signs.

Did you know you can speak to a veterinarian without having to travel? Just head over to PangoVet. It's our online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content Savings V1

What Happens if You Miss a Dose?

If you miss a dose of your dog’s allergy medication, give it when you remember. Do not double up on doses, so if it’s close to the time of the next pill, consider the dose missed.

Sick dog Jack Russell Terrier dog waiting get pill from hand of owner
Image Credit: Liudmyla Guniavaia, Shutterstock

divider dog faces oct 2024

Potential Side Effects of Antihistamines in Dogs

While not all dogs respond effectively to antihistamines, they are relatively safe, even for diabetic dogs. The most common side effect is drowsiness, commonly seen with Benadryl and diabetes or any other condition.

Antihistamines are generally not used in pregnant or nursing dogs because of the possible risk of side effects. Working dogs should not be given an antihistamine without talking to a veterinarian because of the drowsiness factor: you don’t want your working dog sleeping on the job or having its reflexes compromised.

Some dogs will develop paradoxical excitement when antihistamines are used. Ever get the zoomies with Benadryl? Well, some dogs do, too.

The veterinarian may suggest using an antihistamine over a steroid if your dog is a diabetic. Steroids are usually contraindicated with diabetic dogs because they have the tendency to cause insulin resistance2. In fact, chronic steroid usage sometimes causes diabetes in our dogs and cats.

Do not use an antihistamine with a decongestant in it, such as Claritin-D Or Zyrtec-D. These medications can be dangerous for your dog to take. You should also avoid any product with xylitol in it due to the risk of hypoglycemia and liver damage.

divider dog faces oct 2024

Frequently Asked Questions

Are there allergy supplements I can give my diabetic dog?

In most cases, pet supplements are safe to use in your diabetic dog. If they are treats, you’ll need to factor those into your dog’s caloric intake for the day, which can impact their glycemic regulation.

Fish oils like Welactin are commonly used for allergy sufferers and are often well tolerated.

Probiotics may even be beneficial for allergic dogs. The gut makes up a large portion of the immune system, and probiotics can help keep this organ healthy and regulate the bacteria that live in it.

Can diabetic dogs have Apoquel or Cytopoint?

Diabetic dogs can generally take allergy medications like Apoquel and Cytopoint. These medications are likely more effective than antihistamines for your dog, so you should discuss them as an option with a veterinarian.

dog before injection at vet office
Image Credit: Ground Picture, Shutterstock

What dogs should not take Apoquel?

Dogs with parasitic skin diseases like Demodex should not take Apoquel. It may also worsen pre-existing cancers, so typically, dogs with cancer are not prescribed this medication.

divider dog faces oct 2024

Conclusion

If you have an allergic dog, talk to a veterinarian about options. Your dog will likely need more than one treatment, but antihistamines can help control signs of itchiness.


Featured Image Credit: Creative Cat Studio, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.


How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Nom Nom Dog Food Subscription Review 2026: Our Expert’s Breakdown

* Nom Nom now offers a free Storage Tub with any subscription purchase It used to be that if you wanted to feed...

How to Keep Mice Away From Dog Food: 3 Expert Tips & Tricks

Mice are rarely a welcome guest in your home. Not only are they destructive beyond belief, but also they’re highly tenacious. Once you...

St. Bullnard (St. Bernard Pitbull Mix): Info, Pictures, Care & More

Designer dogs, or hybrids, have become quite popular over the last few years. In case you’re unfamiliar, designer dogs are not purebred dogs...

10 Best Modern Dog Houses in 2026 – Reviews & Top Picks

Every dog needs a few things to live its best life, like food, water, shelter, and a couple of awesome toys. Today we’ll...

More related

Can Australian Shepherds Be Left Alone? Vet-Verified Facts & FAQ

The Australian Shepherd is known for their beautiful coat, intelligence, and great people skills. These gorgeous dogs have long been considered family dogs,...

15 Best Gifts for Dogs in 2026 – Reviews & Top Picks

When you’re searching for the ultimate present for your favorite canine, you may notice that you have almost infinite options. Dogs are the...

Are Great Danes Aggressive Dogs? Breed Traits & Determining Factors

While dogs are the most popular pet in America, and many consider them “man’s best friend,” a few breeds are known to have...

Why Do Boston Terriers Lick So Much? 5 Likely Reasons

The Boston Terrier is a small breed characterized by their pointy ears, tuxedo-like coat, and quirky behavior. They give off an air of...

Keep reading

How to Read a Dog Food Label: 8 Vet-Approved Tips

We always want the absolute best for our pets, whether it be the most fun new toys or the coziest beds. Nutrition is certainly no exception to this rule. However, if you’ve gone pet food shopping, you know how overwhelming...

woman with her dog at pet store

Can Dogs Eat Chicken Skin? Vet-Verified Nutrition Facts & FAQ

It’s common knowledge that chicken is good for us, and dogs can absolutely reap the health benefits of chicken, too. However, not all parts of the bird are recommended for your canine companion, and chicken skin can be one of...

Dogster-Can-Dogs-Eat-Chicken Skin

10 Best Dog Foods for Colitis in 2026 – Reviews & Top Picks

So, your dog has been diagnosed with colitis. Colitis is a condition of a dog’s colon, the large intestine, or bowels. It is a common, inflammatory disease that is the main cause of diarrhea. Watching the stress and discomfort your...

white and brown dog eating in a food bowl

Can Dogs Eat Clam Chowder? Vet-Verified Nutrition Facts & FAQ

If you have prepared a hearty bowl of clam chowder, you will undoubtedly notice your dog’s nostrils flaring and tail wagging at the irresistible smell. And while it’s cold out, you may wonder if it’s okay for your companion to...

Can Dogs Eat_Clam Chowder

Can Dogs Eat Mexican Rice? Vet-Verified Facts & Tips

It’s not unusual for people to search for ideas on new things for their dogs to eat. Pet owners want their dogs to enjoy new things from time to time instead of routine dog food. Considering that rice is often...

Can Dogs Eat Mexican Rice

Essence Dog Food Review 2026: Recalls, Pros & Cons

Review Summary In today’s world, it can be hard to figure out which dog food brand is best for your pup. You love your dog and want the best for them. And you know that feeding them the best food...

Dogster_Essence Dog Food Review

Can Dogs Eat Froot Loops? Vet-Reviewed Nutrition Facts

Many of us grew up eating cereal in front of the television while watching cartoons. Of the many cereal choices on the market, one of the most popular is Fruit Loops. These colorful loops are certainly tasty but not very...

Can Dogs Eat Froot Loops

Can Dogs Eat Star Fruit? Vet-Verified Info & Risks

Star fruit or carambola is an appropriately named southeast Asian fruit of the tree of the same name. It’s a global food item grown in the warmer USDA Plant Hardiness Zones of 10 and 11 in the United States.1 Its...

Can Dogs Eat_star fruit