Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Prednisone for Dogs: Our Vet Explains the Uses, Doses & Side Effects

Prednisone Drug In Prescription Medication Pills Bottle

Prednisone is common in both human and veterinary medicine. It’s useful for various ailments, from itchy skin to cancer treatment. While it may work wonders for many conditions, there are a few things to be aware of when giving this medication to canines. Read on to learn about the use of prednisone in dogs, the side effects, and proper doses.

divider single dog paw oct 2024

What Is Prednisone?

Prednisone, also known as PrednisTab or Deltasone, is a type of steroid called a glucocorticoid. It is a human-made version of cortisone, which is naturally produced in a dog’s body. Prednisone is widely used because it is a great multi-tasker that can do multiple things in the body. It is typically prescribed for dogs for three main reasons:

  • Inflammation: Prednisone is a potent anti-inflammatory. It can help reduce pain and discomfort due to all sorts of inflammatory conditions, including osteoarthritis, allergies, itchy skin, asthma, and inflammatory bowel disease.
  • Immune suppression: Sometimes, a dog’s immune system can get slightly out of control, leading to autoimmune diseases like autoimmune hemolytic anemia or lupus. Prednisone helps treat these diseases by dampening the immune system to reduce signs.
  • Replacement therapy: Addison’s disease, or hypoadrenocorticism, occurs when a dog’s body doesn’t produce enough cortisol and other steroids. It can affect nearly every bodily function. Affected canines need regular doses of prednisone to make up for the loss of these hormones in the body

How Is Prednisone Given?

Owner giving medicine in a pill to his dog
Image Credit: Creative Cat Studio, Shutterstock

To give prednisone to your pup, you have a few different options. The most common are pills or a liquid. Your vet can also give your dog an injection at the clinic to quickly get the medication into the body. At home, you may give them prednisone once or twice a day, every other day, or a couple of times a week. It’s variable depending on what you’re trying to treat.

For certain conditions, such as itchy skin, your vet may recommend that you give prednisone at a higher dose at first, then taper it down to a lower dose that still achieves the same results. They will also generally advise you to reduce the dose when finishing treatment. Again, this is all highly variable, so be sure to pay attention to your vet’s instructions, and don’t be afraid to ask questions.

divider single dog paw oct 2024

What Happens If You Miss a Dose of Prednisone for Your Dog?

Since the dose and frequency of prednisone can be variable, it’s important to follow the directions. However, even with the strictest eye, it’s still possible to miss a dose. If that’s the case, there’s no need to worry. Just give the next dose as soon as you remember it. If it’s getting close to the time for your dog’s next dose, skip the missed one, and give the prednisone per the normal schedule. You simply want to avoid doubling up on a dose within 24 hours.

vet administering medicine to pembroke welsh corgi dog
Image Credit: fast-stock, Shutterstock

Potential Side Effects of Prednisone in Dogs

Prednisone may be helpful for nearly every ailment that a dog may have, but it’s not magic. Giving prednisone to your pet can have side effects. Those are generally mild when the medication is given at a normal dose and may include:

  • Increased appetite
  • Increased drinking
  • Increased peeing

You may notice a significant uptick in your dog’s appetite, which can make them beg more and devour their food. You can help satiate your ravenous pup by breaking their daily food amounts into multiple small meals and offering them dog-safe vegetables as snacks between meals.

Long-term use or high doses can increase the severity of side effects, so if your dog shows any of these signs, be sure to contact your vet:

  • Panting
  • Vomiting
  • Diarrhea
  • Behavioral changes

A severe potential side effect of prednisone is gastrointestinal ulceration, which can have signs of:

  • Bloody vomit
  • Bloody or black poop
  • Inappetence

Excess amounts of prednisone can even lead to Cushing’s disease, where the body has too many steroids. Cushing’s may present with:

  • Lethargy
  • Poor hair coat
  • Weight gain
  • Potbelly
  • Muscle wasting

Anything out of the normal can be alarming when your dog is taking prednisone, so be sure to talk to your vet if you’re concerned.

Did you know you can talk to a vet online? Click on the image or button below to schedule a call: PangoVet_Mention-in-Content Savings V1


divider single dog paw oct 2024

Frequently Asked Questions (FAQ)

How Long Does It Take for Prednisone to Help a Dog?

Puppy drinking medicine
Image Credit: Vitaly Titov, Shutterstock

For most dogs, the effects of prednisone start to be noticeable within 1–2 hours of taking it. Of course, that time can vary depending on the condition being treated, but you should still start seeing benefits after a few hours. That may mean less scratching or limping fairly quickly. Prednisone stays in a dog’s system for only about 24 hours.

Can I Stop Giving Prednisone to My Dog After 2 Days?

Even though your dog may feel better almost immediately when taking prednisone, it’s not something that you want to stop short on. While it can decrease your dog’s signs rapidly, you still want to give prednisone a chance to work on the root of those signs. It’s also typically recommended to taper off the dose of prednisone rather than ending it abruptly.

Does Prednisone for Dogs Make Them Sleepy?

Prednisone typically makes dogs restless rather than sleepy, but that doesn’t mean it can’t happen. If your dog seems to be extra sleepy after starting prednisone, speak to your vet.

Sad dog lying on a bed sick with vet plastic Elizabethan collar
Image Credit: Iryna Kalamurza, Shutterstock

Should I Limit My Dog’s Water Intake While They’re on Prednisone?

One of the side effects of prednisone can be increased water intake, with a consequential increase in peeing. While you may be tempted to limit how much water they drink so you don’t have to let them out as often, don’t do that. Water is essential, and your dog should be able to have as much as they want unless you’ve been instructed otherwise by your vet.

divider single dog paw oct 2024

Conclusion

Prednisone is a common medication given to canines for everything from cancer, itchy skin, and pain to autoimmune diseases. Doses and frequency can be tricky to manage, though, so be sure to follow your vet’s instructions to avoid potentially severe side effects. While it’s typically normal for a dog to want to eat and drink more while they’re on prednisone, watch out for bloody vomit or poop, lethargy, or weight gain.

See also: 


Featured Image Credit: luchschenF, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Is Rawhide Dangerous for Dogs? Vet-Approved Risks, Benefits & Alternatives

Rawhide chews are extremely popular, and you can purchase them almost anywhere, including pet stores, so it can be a surprise to learn...

Ask Dr. Paola- Growth, Wheezing & Barking (May 26, 2025)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

How Long Will It Take to Potty Train a Dog? Vet-Approved Facts & FAQ

Potty training is one of the more challenging aspects of owning a dog. If you’re contemplating adding a puppy to your home, you...

What Does Raining Cats & Dogs Mean? Pet Idioms Explained

If you’ve heard the expression, “It’s raining cats and dogs,” you may wonder what it means. Rest assured that it has nothing to...

More related

9 Best Retractable Dog Leashes in 2025 – Reviews & Top Picks

Retractable dog leashes are ideal for those canines that love to explore, but they need to be safe for your dog, you, and...

11 Best Senior Dog Foods in 2025 – Reviews & Top Picks

You’ll start to notice as your puppy grows to adulthood and beyond that, just like humans, their body starts to slow down and...

How Smart Is a Labradoodle? 5 Vet-Approved Training Tips

While you won’t find a specific test ranking the intelligence of hybrid dogs, it’s well-known that the Labradoodle is among the most intelligent...

How Protective Are Pitbulls? Causes & Tips to Control Them

Pitbulls are highly renowned for their endurance, muscular bodies, and high energy levels. They make great family pets because of their loyal and...

Keep reading

Can Dogs Eat Truffles? Vet Reviewed Risks & Benefits

Dogs can eat truffles in moderation, and they are not toxic to dogs. You shouldn’t serve truffles to your dog regularly, however. Doing so can lead to nutritional issues since truffles don’t contain all the nutrients dogs need. Furthermore, because...

Can Dogs Eat Truffles

Can Dogs Eat Teriyaki Sauce? Vet Reviewed Nutrition Facts & FAQ

Teriyaki sauce can spice up many of our meals. However, while it is tasty, it isn’t safe for our canines. Teriyaki sauce contains many ingredients and spices—some of which may be toxic to dogs. For instance, this sauce often includes...

Can Dogs Eat_teriyaki sauce

10 Best Dog Foods for Jack Russells in 2025 – Reviews and Top Picks

Jack Russell Terriers are, without a doubt, a unique breed. The small dog is full of energy, a marvelous digger, and has more love than its little body can hold. While small in size, Jack Russells need a balanced diet...

jack russell terier puppy eating food from bowl

Can High-Protein Dog Food Cause Diarrhea? Vet-Verified Nutrition Facts

Some dogs are more sensitive to the protein in their food than others. For some with sensitive stomachs, high protein can lead to digestion issues, including diarrhea. These canines often need a food lower in protein, though an extremely low-protein...

labrador-retriever-dog-eating

How to Get a Puppy to Eat Dry Food: 10 Tips & Tricks

Owning a puppy can be one of the most hilarious, adorable, heartwarming, and frustrating experiences that anyone can have. Taking care of a puppy has various challenges, and ensuring that they get the right nutrition is one of them. When...

Cocker Spaniel puppy eating

7 Homemade Pupsicle Recipes for Your Dog (Vet Approved)

Almost nothing is better than a cold tasty popsicle on a hot summer day. But why should we be the only ones allowed to eat popsicles? What about dogs? You can definitely make healthy pupsicles and give them to your...

Homemade Pupsicle Recipes for Your Dog

9 Best Salmon Dog Foods in 2025 – Reviews & Top Picks

Many dog owners are choosing to feed their dogs food that contains salmon as the main ingredient because of the benefits this fish has to offer their dogs in terms of nutrition. Salmon is a common ingredient in high-quality dog...

dog eating wet food

Can Dogs Eat Curry? Vet-Verified Facts & FAQ

Generally, dogs should never have curry because, in addition to being spicy and potentially causing stomach upset, it is also made with ingredients like garlic and onion that can be toxic to dogs. If your dog has eaten a small...

Can Dogs Eat Curry