Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Prednisone for Dogs: Our Vet Explains the Uses, Doses & Side Effects

Share

Prednisone Drug In Prescription Medication Pills Bottle

Prednisone is common in both human and veterinary medicine. It’s useful for various ailments, from itchy skin to cancer treatment. While it may work wonders for many conditions, there are a few things to be aware of when giving this medication to canines. Read on to learn about the use of prednisone in dogs, the side effects, and proper doses.

divider single dog paw oct 2024

What Is Prednisone?

Prednisone, also known as PrednisTab or Deltasone, is a type of steroid called a glucocorticoid. It is a human-made version of cortisone, which is naturally produced in a dog’s body. Prednisone is widely used because it is a great multi-tasker that can do multiple things in the body. It is typically prescribed for dogs for three main reasons:

  • Inflammation: Prednisone is a potent anti-inflammatory. It can help reduce pain and discomfort due to all sorts of inflammatory conditions, including osteoarthritis, allergies, itchy skin, asthma, and inflammatory bowel disease.
  • Immune suppression: Sometimes, a dog’s immune system can get slightly out of control, leading to autoimmune diseases like autoimmune hemolytic anemia or lupus. Prednisone helps treat these diseases by dampening the immune system to reduce signs.
  • Replacement therapy: Addison’s disease, or hypoadrenocorticism, occurs when a dog’s body doesn’t produce enough cortisol and other steroids. It can affect nearly every bodily function. Affected canines need regular doses of prednisone to make up for the loss of these hormones in the body

How Is Prednisone Given?

Owner giving medicine in a pill to his dog
Image Credit: Creative Cat Studio, Shutterstock

To give prednisone to your pup, you have a few different options. The most common are pills or a liquid. Your vet can also give your dog an injection at the clinic to quickly get the medication into the body. At home, you may give them prednisone once or twice a day, every other day, or a couple of times a week. It’s variable depending on what you’re trying to treat.

For certain conditions, such as itchy skin, your vet may recommend that you give prednisone at a higher dose at first, then taper it down to a lower dose that still achieves the same results. They will also generally advise you to reduce the dose when finishing treatment. Again, this is all highly variable, so be sure to pay attention to your vet’s instructions, and don’t be afraid to ask questions.

divider single dog paw oct 2024

What Happens If You Miss a Dose of Prednisone for Your Dog?

Since the dose and frequency of prednisone can be variable, it’s important to follow the directions. However, even with the strictest eye, it’s still possible to miss a dose. If that’s the case, there’s no need to worry. Just give the next dose as soon as you remember it. If it’s getting close to the time for your dog’s next dose, skip the missed one, and give the prednisone per the normal schedule. You simply want to avoid doubling up on a dose within 24 hours.

vet administering medicine to pembroke welsh corgi dog
Image Credit: fast-stock, Shutterstock

Potential Side Effects of Prednisone in Dogs

Prednisone may be helpful for nearly every ailment that a dog may have, but it’s not magic. Giving prednisone to your pet can have side effects. Those are generally mild when the medication is given at a normal dose and may include:

  • Increased appetite
  • Increased drinking
  • Increased peeing

You may notice a significant uptick in your dog’s appetite, which can make them beg more and devour their food. You can help satiate your ravenous pup by breaking their daily food amounts into multiple small meals and offering them dog-safe vegetables as snacks between meals.

Long-term use or high doses can increase the severity of side effects, so if your dog shows any of these signs, be sure to contact your vet:

  • Panting
  • Vomiting
  • Diarrhea
  • Behavioral changes

A severe potential side effect of prednisone is gastrointestinal ulceration, which can have signs of:

  • Bloody vomit
  • Bloody or black poop
  • Inappetence

Excess amounts of prednisone can even lead to Cushing’s disease, where the body has too many steroids. Cushing’s may present with:

  • Lethargy
  • Poor hair coat
  • Weight gain
  • Potbelly
  • Muscle wasting

Anything out of the normal can be alarming when your dog is taking prednisone, so be sure to talk to your vet if you’re concerned.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's our online service where you can talk to a vet online and get the advice you need for your dog — all at an affordable price!

PangoVet_Mention-in-Content Savings V1

divider single dog paw oct 2024

Frequently Asked Questions (FAQ)

How Long Does It Take for Prednisone to Help a Dog?

Puppy drinking medicine
Image Credit: Vitaly Titov, Shutterstock

For most dogs, the effects of prednisone start to be noticeable within 1–2 hours of taking it. Of course, that time can vary depending on the condition being treated, but you should still start seeing benefits after a few hours. That may mean less scratching or limping fairly quickly. Prednisone stays in a dog’s system for only about 24 hours.

Can I Stop Giving Prednisone to My Dog After 2 Days?

Even though your dog may feel better almost immediately when taking prednisone, it’s not something that you want to stop short on. While it can decrease your dog’s signs rapidly, you still want to give prednisone a chance to work on the root of those signs. It’s also typically recommended to taper off the dose of prednisone rather than ending it abruptly.

Does Prednisone for Dogs Make Them Sleepy?

Prednisone typically makes dogs restless rather than sleepy, but that doesn’t mean it can’t happen. If your dog seems to be extra sleepy after starting prednisone, speak to your vet.

Sad dog lying on a bed sick with vet plastic Elizabethan collar
Image Credit: Iryna Kalamurza, Shutterstock

Should I Limit My Dog’s Water Intake While They’re on Prednisone?

One of the side effects of prednisone can be increased water intake, with a consequential increase in peeing. While you may be tempted to limit how much water they drink so you don’t have to let them out as often, don’t do that. Water is essential, and your dog should be able to have as much as they want unless you’ve been instructed otherwise by your vet.

divider single dog paw oct 2024

Conclusion

Prednisone is a common medication given to canines for everything from cancer, itchy skin, and pain to autoimmune diseases. Doses and frequency can be tricky to manage, though, so be sure to follow your vet’s instructions to avoid potentially severe side effects. While it’s typically normal for a dog to want to eat and drink more while they’re on prednisone, watch out for bloody vomit or poop, lethargy, or weight gain.

See also: 


Featured Image Credit: luchschenF, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.




How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

From Fighting Ring to Cuddle Monster: Eli and the Importance of Fostering

We all know the importance of adopting pets from animal shelters, and how choosing to bring home a dog from a pet rescue...

Ask Dr. Paola- Help! My Dogs Are Overweight! (April 13, 2026)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

Dogster’s Weekly Photo Contest Winners: Best Easter Photo (April 9, 2026)

Every week our team gets the privilege of sorting through our readers photos to choose what dogs will win this weeks contest! See...

We Didn’t Just Add a Dog to Our Life – We Built a Life With Him

“We didn’t just bring a dog home—we built a life together.” Most people are quietly taught a version of pet ownership that looks...

More related

Can Dogs Eat Turkey Necks? Vet-Verified Nutrition Facts & FAQ

Unless you’re using the turkey neck in a tasty gravy, stock, or soup, many of us can’t think of anywhere else to put...

Can Dogs Eat Cream of Wheat? Vet-Approved Nutrition Facts & FAQ

The grain-free diet craze is dying down among pet owners, leading some to wonder if dogs can eat grain products like Cream of...

6 Best Leash for Dogs That Pull in 2026 – Reviews & Top Picks

Walking your dog can be a fun bonding experience, but it can become frustrating quickly if your dog is pulling you around. Dogs...

How Long Do Pugs Live? Average Lifespan, Vet-Reviewed Data & Care Guide

Pugs are easily one of the most peculiar dogs in the world. They are quirky dogs with flat faces and there is a...

Keep reading

6 Food High in Magnesium for Dogs: Vet-Reviewed Facts & FAQ

Like humans, dogs require essential minerals and vitamins to function. Magnesium, along with calcium, phosphorus, and potassium, is an essential macromineral. It’s important for bone formation, muscle, and nerve function. Magnesium must be included in the diet in sufficient amounts...

dog eating in a food bowl

11 Best Dog Foods for Havanese in 2026 – Reviews & Top Picks

While Havanese are not the most popular small dogs in the United States, there are still quite a few of them out there. If you’re the proud owner of one of these tiny dogs, then feeding them the correct food...

Havanese dog eating

Ollie Fresh Dog Food Review 2026: Pros, Cons & Final Verdict

Ollie Pets delivers fresh premium dog food straight to your door. All the recipes were crafted by experts in the field and contain very nutrient-dense ingredients. If you’re looking to make mealtimes more convenient, you’ll want to consider Ollie. Once...

DOG SAPR OLLIE NEW

Fromm Puppy Food Review 2026: Recalls, Pros & Cons

Review Summary Fromm Family Pet Food started as a silver fox farming company in the early 20th Century before branching out to make dog food in 1949. In the 1970s, the company started manufacturing a line of foods for working...

Dogster_Fromm Puppy Food Review

Can Dogs Eat Mac and Cheese? Vet-Reviewed Nutrition Facts & Safety Guide

When you’re sitting at the kitchen table, it’s a common sight to have your dog giving you puppy eyes, begging for food. But just because they want something doesn’t mean you should give it to them. That’s the case with...

Can Dogs Eat Mac and Cheese

Can Dogs Eat Apple Pie? Vet-Verified Nutrition Facts & Info

We can share a lot of our food items with our dogs, permitting we know the safety and nutritional quality. After all, our dogs are omnivorous just like us. However, when it comes to sweet treats and heavily processed goods,...

Dogster-Can-Dogs-Eat-Apple Pie

Can Dogs Eat Rambutan? Vet-Verified Safety Facts

If your dog is like most, they love to eat. They gobble up their food at every mealtime, go after scraps that fall off the table or counter, and investigate anything that they come across outdoors to see if it...

Can Dogs Eat_rambutan

Solid Gold Puppy Food Review 2026: Recalls, Pros & Cons

Review Summary The Solid Gold dog food brand came to be in 1974 and during the early years, most of their foods contain more natural ingredients that were based on a holistic diet. The company was founded by Sissy Harrington...

Dogster_Solid Gold Puppy Food Review

Love Dogs? So Do We! Join the Dogster Community

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.




Sign up for the Dogster Email Newsletter