Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Prednisone for Dogs: Our Vet Explains the Uses, Doses & Side Effects

Share

Prednisone Drug In Prescription Medication Pills Bottle

Prednisone is common in both human and veterinary medicine. It’s useful for various ailments, from itchy skin to cancer treatment. While it may work wonders for many conditions, there are a few things to be aware of when giving this medication to canines. Read on to learn about the use of prednisone in dogs, the side effects, and proper doses.

divider single dog paw oct 2024

What Is Prednisone?

Prednisone, also known as PrednisTab or Deltasone, is a type of steroid called a glucocorticoid. It is a human-made version of cortisone, which is naturally produced in a dog’s body. Prednisone is widely used because it is a great multi-tasker that can do multiple things in the body. It is typically prescribed for dogs for three main reasons:

  • Inflammation: Prednisone is a potent anti-inflammatory. It can help reduce pain and discomfort due to all sorts of inflammatory conditions, including osteoarthritis, allergies, itchy skin, asthma, and inflammatory bowel disease.
  • Immune suppression: Sometimes, a dog’s immune system can get slightly out of control, leading to autoimmune diseases like autoimmune hemolytic anemia or lupus. Prednisone helps treat these diseases by dampening the immune system to reduce signs.
  • Replacement therapy: Addison’s disease, or hypoadrenocorticism, occurs when a dog’s body doesn’t produce enough cortisol and other steroids. It can affect nearly every bodily function. Affected canines need regular doses of prednisone to make up for the loss of these hormones in the body

How Is Prednisone Given?

Owner giving medicine in a pill to his dog
Image Credit: Creative Cat Studio, Shutterstock

To give prednisone to your pup, you have a few different options. The most common are pills or a liquid. Your vet can also give your dog an injection at the clinic to quickly get the medication into the body. At home, you may give them prednisone once or twice a day, every other day, or a couple of times a week. It’s variable depending on what you’re trying to treat.

For certain conditions, such as itchy skin, your vet may recommend that you give prednisone at a higher dose at first, then taper it down to a lower dose that still achieves the same results. They will also generally advise you to reduce the dose when finishing treatment. Again, this is all highly variable, so be sure to pay attention to your vet’s instructions, and don’t be afraid to ask questions.

divider single dog paw oct 2024

What Happens If You Miss a Dose of Prednisone for Your Dog?

Since the dose and frequency of prednisone can be variable, it’s important to follow the directions. However, even with the strictest eye, it’s still possible to miss a dose. If that’s the case, there’s no need to worry. Just give the next dose as soon as you remember it. If it’s getting close to the time for your dog’s next dose, skip the missed one, and give the prednisone per the normal schedule. You simply want to avoid doubling up on a dose within 24 hours.

vet administering medicine to pembroke welsh corgi dog
Image Credit: fast-stock, Shutterstock

Potential Side Effects of Prednisone in Dogs

Prednisone may be helpful for nearly every ailment that a dog may have, but it’s not magic. Giving prednisone to your pet can have side effects. Those are generally mild when the medication is given at a normal dose and may include:

  • Increased appetite
  • Increased drinking
  • Increased peeing

You may notice a significant uptick in your dog’s appetite, which can make them beg more and devour their food. You can help satiate your ravenous pup by breaking their daily food amounts into multiple small meals and offering them dog-safe vegetables as snacks between meals.

Long-term use or high doses can increase the severity of side effects, so if your dog shows any of these signs, be sure to contact your vet:

  • Panting
  • Vomiting
  • Diarrhea
  • Behavioral changes

A severe potential side effect of prednisone is gastrointestinal ulceration, which can have signs of:

  • Bloody vomit
  • Bloody or black poop
  • Inappetence

Excess amounts of prednisone can even lead to Cushing’s disease, where the body has too many steroids. Cushing’s may present with:

  • Lethargy
  • Poor hair coat
  • Weight gain
  • Potbelly
  • Muscle wasting

Anything out of the normal can be alarming when your dog is taking prednisone, so be sure to talk to your vet if you’re concerned.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's our online service where you can talk to a vet online and get the advice you need for your dog — all at an affordable price!

PangoVet_Mention-in-Content Savings V1

divider single dog paw oct 2024

Frequently Asked Questions (FAQ)

How Long Does It Take for Prednisone to Help a Dog?

Puppy drinking medicine
Image Credit: Vitaly Titov, Shutterstock

For most dogs, the effects of prednisone start to be noticeable within 1–2 hours of taking it. Of course, that time can vary depending on the condition being treated, but you should still start seeing benefits after a few hours. That may mean less scratching or limping fairly quickly. Prednisone stays in a dog’s system for only about 24 hours.

Can I Stop Giving Prednisone to My Dog After 2 Days?

Even though your dog may feel better almost immediately when taking prednisone, it’s not something that you want to stop short on. While it can decrease your dog’s signs rapidly, you still want to give prednisone a chance to work on the root of those signs. It’s also typically recommended to taper off the dose of prednisone rather than ending it abruptly.

Does Prednisone for Dogs Make Them Sleepy?

Prednisone typically makes dogs restless rather than sleepy, but that doesn’t mean it can’t happen. If your dog seems to be extra sleepy after starting prednisone, speak to your vet.

Sad dog lying on a bed sick with vet plastic Elizabethan collar
Image Credit: Iryna Kalamurza, Shutterstock

Should I Limit My Dog’s Water Intake While They’re on Prednisone?

One of the side effects of prednisone can be increased water intake, with a consequential increase in peeing. While you may be tempted to limit how much water they drink so you don’t have to let them out as often, don’t do that. Water is essential, and your dog should be able to have as much as they want unless you’ve been instructed otherwise by your vet.

divider single dog paw oct 2024

Conclusion

Prednisone is a common medication given to canines for everything from cancer, itchy skin, and pain to autoimmune diseases. Doses and frequency can be tricky to manage, though, so be sure to follow your vet’s instructions to avoid potentially severe side effects. While it’s typically normal for a dog to want to eat and drink more while they’re on prednisone, watch out for bloody vomit or poop, lethargy, or weight gain.

See also: 


Featured Image Credit: luchschenF, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.




How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Dogster’s Weekly Photo Contest Winners: This Spot is Mine! (February 26, 2026)

Every week our team gets the privilege of sorting through our readers photos to choose what dogs will win this weeks contest! See...

We Bred English Bulldogs So Extreme They Can’t Mate Naturally

Picture this: A male English Bulldog waddles over to a female in heat, full of confidence and swagger. Then… nothing. His barrel chest,...

Damning Dry Dog Food Report Not What It Seems

Over the past few days, pet and vet communities have been reeling from the revelation that high levels of heavy metals have been...

Ask Dr. Paola- Help! My Dog’s Won’t Stop Barking! (February 23, 2026)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

More related

How Much Is a Teacup Pomeranian? 2026 Price Guide

Having any dog of any size requires the right finances for sure! However, you might think that having a Teacup Pomeranian would be...

How to Use Guillotine Dog Nail Clippers: Vet-Approved Instructions

You’re probably most familiar with standard scissor-style dog nail clippers but may have heard about guillotine-style dog nail clippers before. If you’re unfamiliar...

Great Pyrenees vs Golden Retriever: Key Diffenences Explained (With Pictures)

Selecting the ideal dog for your home can be challenging, but it’s easier when you’ve narrowed down your choices. If you love gentle,...

Black & Tan Shiba Inu: Info, Pictures, Origin & History

The black and tan Shiba Inu might not be the most well-known dog breed out there, but they’re not among the rarest either....

Keep reading

6 Great Sources of Carbohydrates for Dogs: Vet-Verified Nutrition Facts

When it comes to dog nutrition, carbohydrates are a tricky subject. While canines can get energy from protein and fat, many dog food brands contain one or multiple sources of carbs. On the opposite end, there are dog food recipes...

dog eating rice

11 Best Dog Foods for Havanese in 2026 – Reviews & Top Picks

While Havanese are not the most popular small dogs in the United States, there are still quite a few of them out there. If you’re the proud owner of one of these tiny dogs, then feeding them the correct food...

Havanese dog eating

True Chews Dog Treats Review 2026: Pros, Cons, Recalls & FAQ

Review Summary True Chews dog treats are part of the Blue Buffalo line (though they weren’t always) and can be located in most pet stores and online, so you may be familiar with them. The brand offers a fairly good...

Dogster_True Chews Dog Treats Review

Can Dogs Eat Almonds? Vet-Verified Health & Nutrition Facts

Human foods can be quite tempting for our pets, and despite our best efforts to keep them put away, sometimes our pups still get into them. While almonds aren’t technically toxic for dogs like some other nuts, they definitely aren’t...

Can Dogs Eat Almonds

11 Best Dog Foods for Huskies in 2026 – Reviews & Top Picks

If you own a Siberian Husky, then you’re well aware of their high energy levels. But did you know that Huskies also have extremely high metabolisms? This does have something to do with their high energy levels, but it has...

Husky-puppy-eating-from-feeding-bowl-indoors

What Is Fish Meal in Dog Food? Vet-Approved Safety Facts & FAQ

If you’re a dog owner who likes to read pet food labels, you’ll probably find quite a few unfamiliar ingredients listed. One such product is fish meal, commonly found in allergy-friendly diets. But what is fish meal in dog food,...

Wet and dry pet food made of natural ingredients

Can Dogs Eat Kohlrabi? Vet-Approved Facts & Safety Guide

The vegetable kohlrabi might not be very well known to many people and even the name alone might sound kind of foreign. It is characterized by being very similar in appearance and taste to the common cabbage. This nutrient-dense vegetable...

Can Dogs Eat_Kohlrabi

10 Best Dog Foods for Great Danes in 2026 – Reviews & Top Picks

Caring for a Great Dane is an incredible experience but you may have problems locating the ideal food for your massive friend. Numerous companies produce dog food and treats, but fewer meals are designed for extra-large breeds. Great Dane adults...

Great Dane dog

Love Dogs? So Do We! Join the Dogster Community

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.




Sign up for the Dogster Email Newsletter