Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Heterochromia in Dogs: Different Colored Eyes Explained

heterochromia dog

Have you ever noticed a dog with two different colored eyes, or maybe they had two colors in the same eye? What you saw was a condition called heterochromia. Heterochromia can produce beautiful and interesting eye appearances in dogs, but what is it, what causes it, and should you be concerned if your dog has it?

divider dog faces oct 2024

What Is Heterochromia in Dogs?

Heterochromia is a condition in which the eyes are different colors from each other. This means that the irises, the colored part of the eyes, are not the same in both eyes. In most cases, the eyes otherwise appear completely normal.

There are a few types of heterochromia, which we’ll talk about in a minute. This condition can be hereditary, which means that your dog was born with the condition and it began to become visible as they got their permanent eye color around 7 weeks of age. It can also be acquired, which means that some external cause led to a change in the eye colors.

siberian-husky-with-heterochromia-odd-eyes
Image Credit: travelarium.ph, Shutterstock

What Causes Heterochromia in Dogs?

Hereditary heterochromia is closely related to coat color and pattern, with dogs that are dapple, merle, white, or notably white around the head and eyes having a greater likelihood of having the condition. The color of a dog’s irises is determined by how much melanin is present in the eyes. Dogs with brown eyes have a large amount of melanin, while dogs with blue eyes have none in the stroma, the thickest part of the iris and the one that determines eye color. Dogs with heterochromia can have different amounts of melanin in each eye, or they may even have greater and lesser concentrations of melanin in different parts of the iris of the same eye.

Acquired heterochromia is less common than hereditary heterochromia, and it involves some eye conditions. It is caused by external factors that permanently impact the color of the iris in affected dogs. Inflammatory conditions, immune-mediated problems, certain medications, and injuries to the eyes and head can cause acquired heterochromia. In some cases, eye conditions that alter the clarity of the cornea or the eye may be mistaken for heterochromia, like glaucoma or cataracts.

divider single dog paw oct 2024

Types of Heterochromia in Dogs

1. Complete Heterochromia

In complete heterochromia, both eyes are completely different colors from each other. The dog is likely to have one dark eye and one light eye. Most dogs with complete heterochromia have one brown and one blue eye.

border-collie-with-heterochromia_Tattiliana_Shutterstock.jpgDecember 3, 2
Image Credit: Tattiliana, Shutterstock

2. Sectoral Heterochromia

Sectoral heterochromia means that only a section of the dog’s iris is blue, while the rest of the iris is a different color. This can occur in one or both eyes at the same time.


3. Central Heterochromia

Central heterochromia creates a haloed appearance of the iris. In this condition, the iris will have multiple colors within it, with one color radiating from the pupil mixing with the other eye color in a spiky pattern. Like sectoral heterochromia, central heterochromia can impact one or both eyes.

divider single dog paw oct 2024

Are There Health Concerns With Heterochromia in Dogs?

Hereditary heterochromia, the one present in your dog since birth, in and of itself is not dangerous, nor is it associated with causing any health conditions. The only exception to this is that Dalmatians with partial or sectoral heterochromia may have a higher risk of also being deaf.

That said, if you notice any sudden color changes occurring in your dog’s eyes, they should see a veterinarian as soon as possible.

Sudden color changes within the eyes can indicate
  • injury
  • uveitis
  • glaucoma
  • clotting problems
  • cataracts
  • retina problems
  • optic nerve problems
  • corneal degeneration problems

Keep in mind that puppies will have light bluish eyes when they are born, and as they grow, around 7 weeks of age, they will develop their adult eye color, so keep this in mind if you notice color changes within the eyes of a growing pup. However, consult with your vet immediately if in doubt or if they seem to be showing signs of discomfort, eye problems, blindness, deafness, or other conditions.

red-Catahoula-Leopard-Dog-mixed-breed-dog-with-sectoral-heterochromia-in-its-eyes
Image Credit: Marry Swift, Shutterstock

What Breeds Are Most Likely to Have Heterochromia?

Heterochromia can occur in any dog breed; however, it can be seen more often in certain breeds in which ocular color dilution is found.

In Dalmatians, heterochromia seems to occur more frequently in female dogs, but this is not necessarily true in other breeds.

Sudden or gradual changes in eye color and appearance should always be assessed by a veterinarian.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the personalized advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content Savings V1

divider dog paws 3 oct 2024

Frequently Asked Questions

Can Heterochromia Occur in Other Animals?

Yes, heterochromia can occur in cats, as well as humans. It can also occur in horses, cattle, and many other animals. Although more common in animals than in humans, heterochromia is still considered uncommon to rare among all animals it occurs in.

Can Heterochromia in Dogs Be Treated?

Since hereditary heterochromia isn’t considered a problem on its own, there is no need to treat it. If your dog has acquired heterochromia, though, then it’s important to work with your veterinarian to identify the cause. Problems with the eyes are typically considered to be emergencies because some conditions can rapidly result in the loss of vision.

Heterochromia-and-Segmental-Heterochromia in a husky dog
Image credit: Enmanuel Q, Shutterstock

Is Heterochromia Caused by Inbreeding?

Heterochromia can be the result of inbreeding, but the presence of heterochromia doesn’t indicate that inbreeding has occurred. In domestic animals that experience heterochromia, inbreeding may play a role due to the inbreeding that often occurs to develop breeds. However, this inbreeding may have occurred many generations ago. Heterochromia can be caused by a recessive gene, though, which means that two unrelated carriers of the gene may still have offspring with the condition.

Are There Any Cultural Beliefs Surrounding Heterochromia?

Yes, many cultures currently have or previously had beliefs related to heterochromia. Some Native American cultures carry the belief that dogs with heterochromia can see both the earth and the heavens at the same time. In some cases, this belief extends to humans and other animals with heterochromia as well. In some ancient European cultures, heterochromia was associated with witchcraft.

divider dog faces oct 2024

Conclusion

Heterochromia is a fascinating condition that can result in some extremely beautiful and unique eyes. This condition is considered to be harmless on its own, but it can be indicative of a more serious issue. If you have a dog with heterochromia, you should be proud of the uniqueness of your pup!


Featured Image Credit: Jairo Alzate, Unsplash

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Lava and Hela: An Unlikely Bond

Hi, I’m Dr. Maja! Read my introduction to learn more about me and my two crossbreed dogs, Lava and Hela. In June last...

Mini Goldendoodle vs Goldendoodle: Differences Explained (With Pictures)

The Goldendoodle is one of the most beloved mixed-breed dogs, whether they’re a mini or a standard size. These amazing dogs are a...

How Passive-Aggressive Is Your Dog? 7 Signs to Look Out For

Dogs can display various behavioral traits, such as aggression and reactivity. There are various types of dog aggression, and some dog owners wonder...

Aussiedoodle vs Labradoodle: Key Differences (With Pictures)

There are so many types of Doodle breeds out there that it can be a bit overwhelming if you’re looking for one to...

More related

10 Best Dog Shampoos at PetSmart in 2025 – Reviews & Top Picks

If you’re new to the dog shampoo game, you are probably overwhelmed by the numerous choices. With hundreds of shampoo brands, it’s hard...

How Much Does Dog Food Cost in 2025? Average Prices & Buying Tips

Pet food has experienced an inflation rate of about 1.97% per year since 1997. Back then, you could buy the same amount of...

Heybike Mars 2.0 & Pet Accessories Review 2025: Riding in Style With Your Companions

It’s easy enough to load your furry best friend in the car and go on an adventure, but what if you want to...

How to Teach a Dog to Howl: 5 Tips & Tricks

While some pet owners prefer their dogs not to howl, many think it’s fun to teach their pets, and sometimes they’ll howl right...

Keep reading

5 Ollie Dog Food Alternatives in 2025: Comparison & Reviews

When it comes to your dog’s health, Ollie pet food is one fresh-food brand that is becoming increasingly popular. This brand is on a mission to feed dogs with only the best and freshest ingredients available. Unfortunately, as they grow...

dog eating wet food

10 Best Dog Foods for Bichon Frises in 2025 – Reviews & Top Picks

There are a few things to consider when looking at reviews for the best dog food for Bichon Frises. Keep in mind that a few of these options include ingredients for specific diets that are not required unless specified by...

Bichon eating

Can Dogs Have Beets? Vet-Reviewed Nutritional Facts & FAQ

For many people, beets aren’t the first vegetable that comes to mind when they’re at the grocery store or getting ready to make dinner. They are an often maligned and underrated vegetable that adds flavorful depth to dishes, not to...

Beets on a white wooden surface

Can Dogs Eat Cinnamon Toast Crunch? Vet-Verified Nutrition Facts & FAQ

Breakfast is not only the most important meal of the day, but you may think it’s the best one, too. Whether you’re chowing down on pancakes, bacon, oatmeal, or eggs, it’s hard not to love this meal. However, what’s a...

Can Dogs Eat Cinnamon Toast Crunch

Redbarn Dog Food Review 2025: My Food-Sensitive Dog Tries the Most Popular Recipes

It was back in the 1990s when two close friends decided that they wanted to provide high-quality dog food to pets around the nation. Redbarn dog food had its first success with their premium rolled dog food and soon decided...

DOG_SAPR_Redbarn Dog Food

How Much Does Ollie Fresh Dog Food Cost? 2025 Price Guide

Ollie is a premium subscription-based dog food that offers all-natural, human-grade ingredients delivered directly to your door. For many pet owners, a premium diet like this one has a payoff in better health and wellbeing, but it comes at a...

Gizmo a white fluffy dog with Ollie dog food box

What Is Chicken By-Product in Dog Food? Vet-Verified Facts & FAQ

Chicken is the most common first ingredient in dog food. But it’s often followed by “chicken meal,” “chicken by-product,” or “chicken by-product meal.” But what exactly is a chicken by-product? Chicken by-product is simply the part of the chicken that...

man buying pet food

Wag Dog Food Review 2025: Recalls, Pros & Cons

Review Summary When you think of the company Amazon, you may not associate them with dog food. Wag is a fairly new dog food brand that is growing in popularity, and it is entirely owned and produced by Amazon. Wag...

Dogster_Wag Dog Food Review