10 Best Heartworm Medicines for Dogs in 2025 – Reviews & Top Picks

Heartworm disease can be fatal for our beloved dogs, but it’s also very preventable. Regularly administering heartworm medication is highly effective in protecting your dog.

Most heartworm medicines have similar active ingredients. These ingredients can interfere with other treatments and also trigger significant side effects. Therefore, it’s essential to know what’s inside your dog’s heartworm medicine and work with your veterinarian to find one that’s safe for your dog.

Our guide contains thorough reviews of the best heartworm medicines as well as information on common active ingredients. Make sure to read through this guide so that you can find the best heartworm medicine for your precious pup.

A Quick Look at Our Favorites in 2025

Rating	Image	Product	Details
Best Overall		Heartgard Plus	Trusted over 2 billion times Safe for pregnant dogs Safe for Collies	Check Price
Best Value		Tri-Heart Plus Chewable	Affordable Not many side effects Delicious beef flavor	Check Price
Premium Choice		Simparica Trio	Delicious liver flavor Also kills fleas and ticks Doesn’t contain ivermectin	Check Price
		Milbehart Flavored	Safe for 4-week-old puppies Safe for cats Safer for herding breeds	Check Price
		Sentinel Spectrum	Safe for herding breeds Additional protection against fleas Also protects against whipworms and tapeworms	Check Price

The 10 Best Heartworm Medicines for Dogs

1. Heartgard Plus Chew for Dogs – Best Overall

Heartgard Plus Chew for Dogs is a chew that prevents heartworms³ and controls hookworms and roundworms. Each chew also contains real beef, so many dogs find them to be delicious treats that they get to eat once a month.

The formula is safe for puppies over 6 weeks old and pregnant dogs. Collies are often sensitive to the common active ingredients in heartworm medication, but clinical trials proved that Heartgard chews are safe for Collies to eat when given proper doses.

Heartgard has been a trusted brand for many years, and its heartworm chews have a great track record for maintaining customer loyalty. It’s a veterinarian-recommended brand and has been trusted over 2 billion times.

This medication isn’t without side effects. The most common symptoms include vomiting or diarrhea within 24 hours of consumption. If your dog experiences any side effects, make sure to contact your veterinarian right away.

Overall, we think Heartgard Plus Chew for Dogs is the best heartworm medicine for dogs because of its proven effective formula and delicious beef flavor, which makes administering it very easy. It’s also relatively affordable compared to its competitors.

2. Tri-Heart Plus Chewable Tablets for Dogs – Best Value

Tri-Heart Plus heartworm chews have a formula that’s effective against killing heartworm larvae and treating and controlling roundworms and hookworms. The tablets are small in size, and they have a beef flavor to encourage dogs to eat them.

Some dogs rarely experience the listed side effects, so this chew is excellent for dogs with particularly sensitive stomachs. However, you do have to be careful when administering this chew to Collies and other herding breeds. Make sure you closely monitor them for at least 24 hours after administration of this treatment.

Tri-Heart Plus is also one of the most affordable options, so it’s the best heartworm medicine for dogs for the money that you pay.

3. Simparica Trio – Premium Choice

This premium heartworm chew goes beyond protecting your dog from heartworm. It kills fleas and five types of ticks, and it treats and controls roundworms and hookworms. Therefore, even though it’s one of the more expensive heartworm chew options, you can end up saving money because you don’t have to purchase separate flea and tick medication.

The chews also have a liver flavor, so dogs typically enjoy eating them as monthly treats. Dogs can also take it with or without food, so administering this medicine is a rather convenient process.

As with all other heartworm medications, there are some side effects and medical conditions to consider before administering this chew. This medication’s most common side effect is an upset stomach, but it’s a fairly rare occurrence. It’s also an option to consider for herding breed owners because it doesn’t contain ivermectin.

However, keep in mind that this chew hasn’t been evaluated for pregnant or lactating dogs. It also contains sarolaner, which can trigger symptoms in dogs with a history of having seizures.

4. Milbehart Flavored Tablets

Milbehart Flavored Tablets protect puppies and dogs against heartworms, hookworms, roundworms, and whipworms. Puppies as young as 4 weeks old can eat these tablets. They also don’t contain ivermectin. Instead, they have milbemycin oxime, which is generally safe for herding breeds when given in moderate doses. So, they can be a safer alternative for herding breeds.

Milbehart tablets are also safe for cats, so they can be a convenient option for you if you have both cats and dogs in your home. For cats, these chews can remove adult hookworms and roundworms. They also prevent heartworm disease attributed to the species Dirofilaria immitis⁴.

Although Milbehart tablets are safe for very young puppies, it does come with some significant side effects for hypersensitive dogs. Therefore, it’s absolutely crucial to administer the proper dosages and monitor your puppy’s condition for the first few times you administer the tablets

5. Sentinel Spectrum Chew for Dogs

Sentinel Spectrum Chew for Dogs provides protection against five different parasitic worms: heartworms, hookworms, roundworms, whipworms, and tapeworms. It also prevents flea eggs from hatching. Therefore, although it tends to have a higher price than other heartworm medicines, it provides more comprehensive protection against parasites.

The chew’s formula contains active ingredients that are safe for herding breeds. However, it hasn’t been evaluated for pregnant or lactating dogs. Each chew has a beef flavor to encourage dogs to eat them. However, many customers have reported that their dogs don’t like the taste.

Most dogs can safely eat this medicine. However, since it does have several significant side effects, be extra cautious with dogs with hypersensitivities.

6. Advantage Multi Topical Solution for Dogs

If you’re struggling to find a heartworm chew that your dog likes, Advantage Multi Topical Solution is a considerable option because it’s a topical treatment. Instead of oral administration, you apply the formula between your dog’s shoulder blades.

Along with protecting your dog from heartworms, this treatment also kills adult fleas and treats and controls roundworms, hookworms, whipworms, and sarcoptic mange. Studies for this medicine also showed that it doesn’t interfere with many other treatments, including the following:

However, if your dog has sensitive skin, be extra careful with administering this medicine. It can cause some irritation, including pruritus.

7. Trifexis Chewable Tablet for Dogs

Trifexis Chewable Tablet for Dogs has a powerful formula that disrupts the heartworm life cycle and kills fleas. It’s also effective against hookworms, roundworms, and whipworms.

Clinical tests show that this formula doesn’t trigger severe side effects. It’s also a safe option to consider for herding breeds. However, it isn’t meant for young puppies, and you should wait until your dog is at least 8 weeks old before administering this medicine.

The formula also contains artificial beef flavoring, which can be delicious for some dogs. Unfortunately, many dogs aren’t fooled by the flavor, and you might have to mask the chew with pill pockets or other delicious snacks, such as peanut butter.

8. Selarid Topical Solution

Selarid Topical Solution is a broad-spectrum topical treatment that fights against heartworm disease, fleas, ear mites, mange, and ticks. Since it’s a topical treatment, it’s a great option to try on dogs with picky tastes. Just remember that topical treatments can cause localized skin irritation, so be extra cautious if your dog has sensitive skin.

The active ingredient is selamectin, which doesn’t cause any particular adverse effects on herding breeds. It’s also very rare for dogs to experience side effects. This formula is also safe for cats, so if you have multiple pets in your home, make sure to consider this option.

9. Interceptor Plus Chew for Dogs

Interceptor Plus Chew for Dogs is a monthly chew that protects your dog against heartworm infestations, and it also treats and controls adult roundworms, hookworms, whipworms, and tapeworms.

The chew is also infused with delicious chicken flavoring to encourage your dog to eat it. Your dogs can eat it as a treat, your cat can mix it with their food.

These chews are a great broad-spectrum treatment against common intestinal parasites. However, it’s important to note that they’re not safe for puppies under 6 weeks old and pregnant or lactating dogs.

10. Iverhart Max Chew for Dogs

This broad-spectrum chew is soft and easily digestible, and it also has an enticing bacon flavor. Along with protecting your dog against heartworm disease, it also treats and controls roundworms, hookworms, and tapeworms.

The medication can potentially cause several different side effects, and it hasn’t been evaluated for pregnant or lactating dogs. It also contains ivermectin, so if you have a herding breed, you have to be extra careful about the dosage or avoid administering it at all.

Although the chews are marketed as soft, some customers have reported that the packaging doesn’t adequately contain the chews’ moisture and dries them up.

Buyer’s Guide: How to Choose the Best Heartworm Medicine for Your Dog

Still not sure which heartworm medication is the right one for your pup? We’ll help you narrow in on the top choice based on the important variables highlighted below.

Active Ingredients

Heartworm medicines use several common active ingredients. It is essential to be well-informed about these ingredients because dogs can have allergies or other sensitivities. Some of these ingredients can also have severe side effects.

When shopping for heartworm medicine for dogs, you’ll most likely come across the following ingredients.

Ivermectin

Ivermectin is one of the most common active ingredients in heartworm medicine. It can also treat other intestinal parasites and mites. This ingredient doesn’t typically cause any side effects when you give proper dosages to your pets. The most common side effect is an upset stomach.

It’s important to remember that herding breeds, such as Collies, can have an ivermectin sensitivity due to a genetic mutation. This mutation is individualized, so it’s not in all herding breed dogs.

Ivermectin also interferes with some treatments, such as the following:

Make sure to let your veterinarian know of any other medications your dog takes.

Milbemycin Oxime

Milbemycin oxime is another standard preventative treatment against heartworms and other internal parasites. It’s also often combined with flea medication to develop a broad-spectrum formula for dogs. This ingredient is usually administered orally, and dogs can take it with or without food. If your dog experiences an upset stomach, try serving it with some food.

Milbemycin oxime can interact with other drugs, including cyclosporine, amiodarone, diltiazem, azole antifungals, and erythromycin. It can also interfere with some vitamins and supplements.

Pyrantel

Most heartworm medications don’t exclusively fight against heartworms. They often include other dewormers for other internal parasites. Pyrantel is a common active ingredient that gets integrated with ivermectin. It’s a dewormer that treats roundworm, hookworm, and other stomach worms.

Side effects aren’t too common, but they include vomiting, nausea, lack of appetite, and diarrhea. Vomiting can occur due to an empty stomach, so it’s safe to give this medication with food. Along with vomiting, diarrhea and a lack of appetite can be due to parasites getting eliminated from the body.

Pyrantel is often safe for pregnant and nursing animals, but you must be extra mindful of administering the proper dosage. Some pets can also be allergic to it. It interferes with several other drugs including levamisole, morantel, piperazine, and organophosphates.

Selamectin

Selamectin is an antiparasitic that treats heartworms, fleas, ear mites, scabies, and some ticks. It’s administered topically on unbroken skin. Since it’s topical, it’s important that dogs don’t get a bath within 2 hours of contact.

This ingredient is often safe for pregnant dogs. However, similar to ivermectin, herding breeds can be extra sensitive to it.

Selamectin can interfere with other medications:

Moxidectin

Moxidectin can be administered orally and topically. It’s an antiparasitic that treats intestinal worms and mange on top of heartworms. It’s also often combined with imidacloprid to treat fleas. When administered topically, make sure not to bathe your dog for the next 4 days.

Side effects are uncommon. However, some dogs with milbemycin sensitivities can experience fatal symptoms with moxidectin. Therefore, it’s imperative to consult with a veterinarian before using moxidectin.

There aren’t any reports of moxidectin interfering with specific medications. However, it should be administered with caution if your dog is on a benzodiazepine treatment.

Our Selection Process For Heartworm Medicines For Dogs

To create this buyer’s guide, our writing team and editorial staff checked customer reviews, brand reputation, and veterinary approval ratings to present the heartworm medicines we think should be highlighted for our readers. In some cases, we conducted hands-on testing along with seeing how much our dogs liked the heartworm medicines. All these factors were considered when selecting these listed heartworm medicines to help you make the best purchase for your furry friends.

Why Trust Dogster?

Since 2004, Dogster has been a trusted brand for dog owners online, which means we have a lot of experience with heartworm medicines. We take pride in promoting the well-being of all dogs—from toy breeds to giant canines. Our in-house veterinarians, writers, and editors examine each product on our lists, ensuring its quality and reputation. As pet owners ourselves, we only want the best for our furry companions. At Dogster, we are transparent about the products we promote. The nutritional information, overall brand reputation, and customer reviews are all considered for these lists. We inform you how we want to be informed.

Conclusion

Based on our reviews, Heartgard Plus Chew for Dogs is the best heartworm medication because it has a potent formula. It also has a proven track record that effectively protects dogs against heartworm disease. Simparica Trio is another great option because it provides broad-range protection against many parasites.

Overall, the most important thing you can do for your dogs is to understand the active ingredients in heartworm medicine and work with your veterinarian to find the safest option for them. Heartworm medicine is essential to dogs’ health, and it can greatly increase dogs’ lifespans and improve their quality of life.

See also:

• Can Heartworm Cause Long-Term Effects in Dogs? Our Vet Explains
• I Forgot to Give My Dog Their Heartworm Pill, What Should I Do? Our Vet Answers

Featured Image Credit: ThamKC, Shutterstock