Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

My Dog Has a Lump After Their Rabies Shot: Should I Worry? (Vet Answer)

veterinarian injecting a dog with vaccine

You are petting your dog a day or two after they got vaccinated, and you feel a strange bump near the site where they received their injection. Is this lump normal after getting a rabies vaccine, or do you need to contact your vet right now?

divider single dog paw oct 2024

Should I Worry About a Lump After My Dog Gets a Vaccine?

If it’s just a small lump, you shouldn’t immediately worry, but you should be mindful of the swelling and monitor it closely. If there’s any drainage from the site, you should contact your veterinarian as soon as possible to have them take a peek at your pup.

Typically, these lumps will go away within a couple of weeks. They may be a little tender to the touch the first couple of days, but that often fades rather than getting worse.

If you are far from a vet clinic and need urgent vet advice and guidance on the best course of action you can chat with a vet online.

Did you know you can talk to a vet online? Click on the image or button below to schedule a call: PangoVet_Mention-in-Content Savings V1


What Causes a Lump at a Vaccine Site?

Lumps at the site of a vaccine injection are relatively common and signal that the body’s immune system is gearing up to develop an immune response. When the vaccine is injected under the skin, inflammatory cells will accumulate at the site. Fluid and red blood cells can also clump up here, making a small knot. You’ll also get a small bump from the vaccine fluid injected under the skin, usually only about one milliliter (mL or cc).

In rare situations, your dog could develop an infection from the vaccination if bacteria or other microbes get under the skin during the injection. Your dog could develop an abscess. These swellings are often large, painful, reddened, or erythematous and may have purulent drainage.

It’s also important to note that your dog might be a little tired or under the weather for a day or two after their vaccines. If they have weakness or collapse, difficulty breathing, pale gums, vomiting, diarrhea, or facial swelling, they need to be evaluated by a veterinarian immediately.

close up dog with skin lump
Image Credit: Todorean Gabriel, Shutterstock

Testing the Lump

If the swelling after a rabies vaccine or other vaccination persists or gets larger, you should have your dog examined by a veterinarian. They can take a fine needle aspirate to correct a cytology sample and look for abnormal cells.

If the vet sees evidence of an inflammatory response, they may just have you continue monitoring your dog. If they see pus at the site, they’ll likely culture the area and put your dog on antibiotics to treat the infection. Tumor cells could mean a rare vaccine-related tumor or a tumor near the vaccination site.

Vaccine-associated tumors are rare in dogs, but they are possible. They tend to be a bit more common in cats, particularly after receiving a feline leukemia or rabies vaccine.

Treating a Lump After Your Dog Is Vaccinated

Talk to your veterinarian before giving your dog anything for the lump after vaccines. The doctor may often suggest giving your dog oral Benadryl (diphenhydramine) to help control the immune response.

Your dog’s vet might also prescribe anti-inflammatory medications, such as Rimadyl (carprofen) or Metacam (meloxicam).

If the swelling persists or worsens, speak to your veterinarian about other options. If the site is infected, your dog may need antibiotics. Sometimes, a compress can alleviate some swelling and discomfort. In rare circumstances, your dog could have minor surgery to remove or drain the lump.

hand holding syringe for rabies vaccine with a black dog in the background
Image Credit: Numstocker, Shutterstock

divider single dog paw oct 2024

Frequently Asked Questions (FAQ)

What Are Vaccine Reactions in Dogs?

Compared to the number of vaccines administered daily, vaccine reactions in dogs are rare. A 2005 study published in JAVMA determined that the rate of vaccine reactions was 38.2 events per 10,000 dogs. This study included any sort of documented adverse reaction.

The most common side effects of vaccination include lethargy, soreness, and a slight swelling at the injection site.

Some dogs do have vaccine reactions. Gastrointestinal signs may occur, including vomiting and diarrhea. More severe allergic reactions can include facial swelling and hives. Some pets get a little puffy around their muzzle or eyes, while others have full-blown facial swelling. If you see these, contact your veterinarian immediately.

In rare cases, dogs can develop severe anaphylaxis to a vaccine. They could collapse and go into shock. This type of reaction typically occurs shortly after your dog is vaccinated.

dog getting a vaccine
Image Credit: Syda Productions, Shutterstock

How Long Does It Take a Lump After Vaccines to Go Away?

Most of the time, lumps from a vaccine go away within a couple of weeks of your dog getting a vaccine. If the swelling continues past that point, your veterinarian definitely needs to examine your dog.

divider single dog paw oct 2024

Conclusion

While it is not uncommon for dogs to develop swelling at their injection site, it can be worrisome for pet owners. Keep lines of communication with your vet so they can advise you on the next steps, especially if the lump doesn’t go away within a few days.


Featured Image Credit: Oleg Kopyov, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

ThunderLeash Review (2025): Pros, Cons & Final Verdict

ThunderWorks is an innovative pet-focused company focusing on manufacturing affordable, effective, and easy-to-use solutions for many of the problems pet owners face. The...

200 Popular Dog Names for Australian Cattle Dogs: Fun Ideas For Your Pup

Australian Cattle Dogs were originally developed in Australia for droving cattle over long distances, across rough terrain. They are a hardy and spirited...

Why Do Dogs Lick Your Feet? Vet-Reviewed Reasons & Solutions

Whether you love it or hate it, one thing is for sure: your dog just loves to lick your feet! It’s hard to...

6 Creative Life Hacks for Living With Dogs (2025 Guide)

Spouses can mirror one another in many different ways. My husband and I, for example, both inherited a fairly frugal, non-fancy nature from...

More related

10 Best Dog-Friendly Vacation Destinations in Canada (2025 Guide)

Canada is a beautiful country with stunning scenery and lovely people. But is Canada dog friendly? Well, another aspect that makes the country...

How Aggressive Is a Maltese? Factors, Prevention & FAQ

The Maltese dog breed is known for its small size, silky white coat, and affectionate nature, but don’t let them fool you. While...

Fungal Infections in Dogs: Signs, Causes & Treatment (Vet Answer)

A number of fungal infections can affect our canine companions. Some of these fungal infections are superficial or “local” diseases, such as ringworm...

Why Is My Dog Limping? 7 Vet-Reviewed Causes & What to Do

If your normally active dog slows down and starts favoring one leg, it’s natural for you to worry. Limping and lameness are non-specific...

Keep reading

9 Best Grain-Free Senior Dog Foods in 2025 – Reviews & Top Picks

If you’re considering putting your dog on a grain-free diet, please speak to your vet first. But if your vet has sent you on a quest to find grain-free food for your senior dog, you’ve come to the right place....

close up of a dog eating from the bowl

9 Best High-Fiber Dog Foods in 2025 – Reviews & Top Picks

While dogs are often thought of as being mostly meat eaters, fiber also plays an important role in maintaining the good health of our canine companions, especially their digestive system. Dietary fiber is part of edible plants that can’t be...

Schnauzer puppy dog eating tasty dry food from bowl

8 Best Dog Foods for American Bullies in 2025 – Reviews & Top Picks

American Bullies are a new breed with old roots. They’re closely related to Pit Bull Terriers and Bulldogs, and their strong, muscular forms require a lot of fuel. When you’re looking for food to keep your Bully going, look for...

American Bully eating

Are Pig Ears Good for Dogs? Vet-Verified Facts & Guide

Pig ears have been popular dog treats for quite a while, but it’s always a good idea to investigate whether any treat is suitable for your dog. When it comes to pig ears, the answer is “sort of.” Pig ears...

Pig Ears

Can Dogs Eat Rice Pudding? Vet-Approved Facts & FAQ

Anyone who owns a dog knows how it feels to be enjoying a yummy snack only to look over and see big, begging eyes watching each bite you take. With the close relationship we share with our dogs, it’s only...

Can Dogs Eat_rice pudding

Can Dogs Eat BBQ Chips? Vet-Approved Facts & FAQ

When you’re enjoying a bag of BBQ potato chips and your dog hits you with those pleading eyes, you might wonder if it would be okay to give your dog a few chips. Are they safe for dogs? Generally speaking,...

Can Dogs Eat_bbq chips

10 Best Dog Foods for Autoimmune Disease in 2025: Vet Approved Reviews

Like humans, dogs have an immune system to protect them from illness and disease. When this natural defense system can’t distinguish between foreign cells and the body’s own cells, it can turn on itself. An autoimmune disease is when the...

Dog-with-a-full-food-bowl_nancy-dressel_shutterstock

Can Dogs Eat Eggplant? Vet-Reviewed Facts & FAQ

Although your dog may want to eat just about everything in your house, there are a lot of foods that must be kept out of their reach for their own safety. Food products such as chocolate and avocado or anything...

Can Dogs Eat Eggplant