Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Allergy Medicine for Diabetic Dogs: What Is Safe for Them to Take (Vet Answer)

Owner giving medicine in a pill to his dog

Your pup is itchy, and it’s keeping you up—no wonder you’re interested in allergy medication for your dog. The question is, what kind of allergy medication can your dog take because it’s diabetic? Let’s look at some allergy medications and see what your furry family member can take to help you both get some sleep tonight.

divider dog faces oct 2024

What Is an Antihistamine?

An antihistamine is an allergy medication that helps block the effects of histamine on the body. These medications come in many forms and tend to be effective at controlling many allergy signs and symptoms.

Unfortunately, in dogs, signs of allergies aren’t just caused by histamine; they’re also caused by inflammatory cells like cytokines. Most dogs don’t have itchy, watery eyes as part of their allergy manifestation; they tend to develop ear infections and lick their paws. As such, many dogs are not well controlled by antihistamines. One study showed that only 27% of dogs responded well to antihistamines1.

The most commonly used antihistamines in dogs are human medications that veterinarians use off-label.

Some of these that are safe for diabetic dogs include:
  • Diphenhydramine (Benadryl)
  • Cetirizine (Zyrtec)
  • Loratadine (Claritin)
  • Chlorpheniramine (Chlor-Trimeton)
  • Hydroxyzine (Atarax)

A veterinarian might recommend a newer medication to control your dog’s allergies that isn’t an antihistamine.

These medicines include:
  • Apoquel
  • Cytopoint
  • Atopica

Many dogs need a multipronged approach to treat allergies. These treatments can include topical products, such as shampoos. Many veterinarians recommend omega-3 fatty acid products, such as Welactin, to help decrease inflammation and itchiness.

woman and labrador dog consulting with the vet
Image Credit: SeventyFour, Shutterstock

divider dog faces oct 2024

How Are Allergy Medications Given to Dogs?

Most allergy medications, especially antihistamines, are given to dogs in tablet form. These are generally unflavored tablets, but some are available in a liquid formulation.

Apoquel is only available as a tablet, but the company has made a chewable tablet to help encourage dogs to take the medication. Cytopoint is an injection that the veterinarian administers every 4 to 8 weeks. Atopica is usually used in a capsule formulation, but some small dogs can utilize the liquid cat version.

Antihistamines do not usually have interactions with insulin and can typically be given at similar times. Atopica and Cytopoint manufacturers do not report any interactions with insulin treatment either, but it is best to follow the veterinarian’s guidelines to ensure the safest and most effective treatment plan for your dog.

Talk to a veterinarian about whether an antihistamine or other allergy medication might be effective for your dog’s allergy signs.

Did you know you can speak to a veterinarian without having to travel? Just head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content Savings V1

What Happens if You Miss a Dose?

If you miss a dose of your dog’s allergy medication, give it when you remember. Do not double up on doses, so if it’s close to the time of the next pill, consider the dose missed.

Sick dog Jack Russell Terrier dog waiting get pill from hand of owner
Image Credit: Liudmyla Guniavaia, Shutterstock

divider dog faces oct 2024

Potential Side Effects of Antihistamines in Dogs

While not all dogs respond effectively to antihistamines, they are relatively safe, even for diabetic dogs. The most common side effect is drowsiness, commonly seen with Benadryl and diabetes or any other condition.

Antihistamines are generally not used in pregnant or nursing dogs because of the possible risk of side effects. Working dogs should not be given an antihistamine without talking to a veterinarian because of the drowsiness factor: you don’t want your working dog sleeping on the job or having its reflexes compromised.

Some dogs will develop paradoxical excitement when antihistamines are used. Ever get the zoomies with Benadryl? Well, some dogs do, too.

The veterinarian may suggest using an antihistamine over a steroid if your dog is a diabetic. Steroids are usually contraindicated with diabetic dogs because they have the tendency to cause insulin resistance2. In fact, chronic steroid usage sometimes causes diabetes in our dogs and cats.

Do not use an antihistamine with a decongestant in it, such as Claritin-D Or Zyrtec-D. These medications can be dangerous for your dog to take. You should also avoid any product with xylitol in it due to the risk of hypoglycemia and liver damage.

divider dog faces oct 2024

Frequently Asked Questions

Are there allergy supplements I can give my diabetic dog?

In most cases, pet supplements are safe to use in your diabetic dog. If they are treats, you’ll need to factor those into your dog’s caloric intake for the day, which can impact their glycemic regulation.

Fish oils like Welactin are commonly used for allergy sufferers and are often well tolerated.

Probiotics may even be beneficial for allergic dogs. The gut makes up a large portion of the immune system, and probiotics can help keep this organ healthy and regulate the bacteria that live in it.

Can diabetic dogs have Apoquel or Cytopoint?

Diabetic dogs can generally take allergy medications like Apoquel and Cytopoint. These medications are likely more effective than antihistamines for your dog, so you should discuss them as an option with a veterinarian.

dog before injection at vet office
Image Credit: Ground Picture, Shutterstock

What dogs should not take Apoquel?

Dogs with parasitic skin diseases like Demodex should not take Apoquel. It may also worsen pre-existing cancers, so typically, dogs with cancer are not prescribed this medication.

divider dog faces oct 2024

Conclusion

If you have an allergic dog, talk to a veterinarian about options. Your dog will likely need more than one treatment, but antihistamines can help control signs of itchiness.


Featured Image Credit: Creative Cat Studio, Shutterstock

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Portuguese Water Dog: 7 Surprising Facts

The Portuguese Water Dog, often called the Portie or PWD, is a little-known breed with an infectiously joyous personality, lustrous curly coat, and...

Golden Havanese (Havanese & Golden Retriever Mix): Info, Pictures, Care & More

The Golden Havanese is a unique mix that you may have a hard time finding unless. Most intentional designer dogs involve pups about...

12 Dog Breeds Similar to Pitbulls (With Info & Pictures)

There are hundreds of dog breeds out there, and they all have their unique traits. Naturally, some of these dogs look and act...

Can Dogs Eat Cicadas? Vet-Reviewed Health Concerns

If cicadas have started their emergence in your area, you may be concerned about more than just their high-pitched sound. These flying insects...

More related

10 Best Puppy Foods for Chihuahuas in 2025 – Reviews & Top Picks

One of the best-known toy breeds, the Chihuahua is a small, energetic dog bursting with personality. Most Chihuahua owners take their dogs everywhere,...

8 Dog Smoothie Recipes Your Pup Can Enjoy Today

Dogs are omnivores that can enjoy many of the same fruits and vegetables that humans can eat. There are many potential benefits to...

How to Potty Train a Bernese Mountain Dog: 9 Vet Approved Tips (With Pictures)

One of the most frustrating parts of bringing a new dog into the home is potty training them. And with a Bernese Mountain...

How Do Search & Rescue Dogs Find Missing People? The Fascinating Answer

Dogs play many roles in our everyday lives. Some are companions, others are used for farm work, and many are employed as service...

Keep reading

Can Dogs Have Persimmons? Vet-Verified Nutrition Facts & FAQ

Persimmons make a versatile addition to the kitchen and infuse foods with a delightful sweetness and unique health benefits that parents, kids, and even our pets can enjoy. Dogs can eat persimmons as an occasional treat without issue if you...

Dogster-Can-Dogs-Have-Persimmons

Are Greenies Good for Dogs? Vet-Approved Nutrition Guide

Dental disease is one of the most common canine health problems. Dental problems can be painful and make it difficult for dogs to eat. Severe periodontal disease can make dogs more vulnerable to tooth root abscesses and organ disease. That’s...

Greenies bites out of package

Jiminy’s Dog Food Review 2025: Pros, Cons & Verdict

Review Summary Introduction Insects are full of essential proteins and nutrients and are a sustainable food source. Jiminy’s uses crickets to provide dogs with an excellent source of protein. It is also beneficial for dogs with food allergies and is...

Dogster_Jiminy’s Dog Food Review

Can Dogs Eat Corn Chips? Vet-Verified Info, Risks & Alternatives

Our canine companions aren’t picky eaters; they’ll eat anything and everything they come across. So, it isn’t uncommon for our pups to beg for a bite of whatever we’re eating. While feeding your dog human food shouldn’t be something you...

Dogster-Can-Dogs-Eat-Corn Chips

10 Best Grain-Free Dog Food in Australia in 2025 – Reviews & Top Picks

Looking for the best grain-free dog food in Australia? Look no further! We’ve got you covered with our comprehensive reviews of the top grain-free dog foods on the market. Be sure to speak with your veterinarian if grain-free is required...

Ziwi Peak Air-Dried Dog Food new

7 Dog Cupcake Recipes You Can Make At Home Today

Dog cupcakes may seem like fancy treats saved for special occasions. However, they can be healthy snacks that you can make for your dog at any time of the year. Homemade dog cupcakes use natural ingredients, and you can control...

Dog Cupcake Recipes You Can Make At Home Today

9 Best Dog Foods for Seizures in 2025: Reviews & Top Picks

Seizures are a growing concern amongst dog parents and one that is understood as little by veterinarians as it is by dog owners. While there is debate on the cause and necessary treatment for seizures in dogs, there’s no doubt...

Dog beagle eating canned food from bowl in bright interior

How to Calculate Pet Food Dry Matter Basis (With Calculator)

What is dry matter basis and why is it important for pet food? We’ve got the answers—and a calculator—to help you determine the ratio of nutrients to moisture content. When looking at the nutritional values of pet food, the guaranteed...

dry dog food in plastic bag and dog head