Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

First Vaccines For Puppies: Our Vet’s Guide on Initial Vaccinations

Cute labrador puppy dog getting a vaccine at the veterinary doctor

Bringing a new puppy into your home can be both exciting and overwhelming. You’ll undoubtedly experience the joy that comes with puppy cuddles, playtime, and watching them grow. There’s also a lot to think about—feeding, exercise, toilet training, and vaccinations. But vaccinations don’t need to be stressful.

This article will discuss what to expect, which vaccinations are most important, the possible side effects of vaccinations, and what will happen with vaccinations in the future.

divider dog paws 3 oct 2024

What Happens at Puppy Vaccinations?

Puppy vaccinations are more than just a vaccination. In fact, they are a consultation with a veterinarian. This comprises a full physical exam, checking every part of your puppy from the nose to tail. It is a chance for your vet to assess your puppy’s overall health and check for any hereditary abnormalities.

It is also a chance to discuss training, parasite prevention, and de-sexing. All of these aspects of canine care will be unique to you and your dog – there is no “one size fits all” approach.

The vaccination itself is an injection given under the skin, generally in the scruff of the neck. Depending on the brand and type of vaccination, more than one injection may be necessary. Some forms of “kennel cough” vaccines (see below) are given orally (into the mouth) or intranasally (into the nostril).

Puppy Vaccine
Image Credit: gorillaimages, Shutterstock

Why Do Puppies Need Vaccinations?

Puppies need vaccinations for the same reasons children and people do: to protect against potentially fatal diseases. For the first few weeks of a puppy’s life, they receive antibodies through their mother’s milk. Antibodies are what the immune system sends out to fight foreign substances like viruses and bacteria.

After a few weeks, the levels of these antibodies diminish, as puppies suckle less milk. This puts them at risk of falling ill if they come into contact with infectious diseases. Vaccinations are then given to “train” the dog’s immune system to fight a disease, preparing the body for an effective immune response.

Which Dog Vaccinations Are Necessary?

The first vaccination is generally given between 6 and 8 weeks of age.

Essential Puppy Vaccinations

  • Parvovirus
  • Adenovirus (viral hepatitis)
  • Distemper virus (These vaccines are usually combined into a single injection, sometimes referred to as a “C3” or “DHP” vaccination)
  • Rabies virus (mandatory in the USA)

Strongly Recommended Vaccinations

Optional Vaccinations

  • Leptospira (different “strains” exist)
  • Lyme Disease
  • Rattlesnake toxoid (These vaccinations may or may not be recommended, depending on where you live and your dog’s level of risk. They are given on a “case-by-case” basis)
Cute Labrador puppy getting a vaccine
Image Credit: ARVD73, Shutterstock

Are There Any Side Effects with Dog Vaccinations?

Thankfully, dog vaccinations are very safe and side effects are rare. Side effects sometimes encountered include:

  • Lethargy or reduced appetite
  • Vomiting
  • Swelling of the face and neck
  • Hives
  • Swellings or tenderness at the injection site

We recommend contacting a veterinarian if you notice any of these signs at home.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's our online service where you can talk to a vet online and get the advice you need for your dog — all at an affordable price!

PangoVet_Mention-in-Content Savings V1

divider dog paws 3 oct 2024

How Long Before My Dog Is Protected?

Generally, puppies are considered immune 7 days after their second vaccination. Until they have had their final puppy vaccination, it’s best to avoid high-density doggy areas such as dog parks and beaches.

When Is the Next Round of Vaccinations Due?

The second round of vaccinations is given one month after the first. Your vet will discuss with you when the final vaccine is due; this is usually at or just after 16 weeks of age.

black dachshund getting a vaccine
Image Credit: Masarik, Shutterstock

divider dog paws 3 oct 2024

Conclusion

Vaccines are a safe, easy, and affordable way to reduce the risk and incidence of preventable canine diseases. Don’t underestimate the importance of puppy vaccinations. At the same time, don’t let puppy vaccinations stress you out. Remember, your vet will guide you through which vaccinations are best and when vaccinations will be due.


Featured Image Credit: ARVD73, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

10 Dog Food Trends in 2025: Pet Food Industry Facts & Statistics

Note: This article’s statistics come from third-party sources and do not represent the opinions of this website. With today’s consumers enjoying better education...

Berniefie (Bernese Mountain Dog Newfoundland Mix): Info, Pictures & More

Berniefies are mixes of Bernese Mountain Dogs and Newfoundlands. They’re likely to be enormous, and a Berniefie can weigh 90 to 150 pounds....

Can Dogs Eat Nuts? Vet-Reviewed Health & Safety Explained

Nuts are nutritional powerhouses, providing humans with a hefty dose of “good fats” and even potentially improving heart health.1 As nutritious as they...

How Big Will My Havanese Get? Average Size & Growth Chart

How big a puppy grows is quite a necessary consideration when adding certain breeds to your household, including a toy dog like the...

More related

10 DIY Dog Christmas Card Ideas You Can Make Today (With Pictures)

The holiday season is the perfect time to show off your beloved furry friend to family and friends. And what better way to...

Why Does My Dog Burp So Much? Vet-Reviewed Causes & When to Worry

Burping is a natural reaction, typically a reaction to ingesting too much air. It is common in dogs, who don’t know that it’s...

Male vs Female Basset Hounds: What’s the Difference? (With Pictures)

The pros and cons of male and female animals have been hotly debated since probably the beginning of pet ownership! There are all...

Dogster Photo Contest: Dogs of the Week Winners (December 4, 2025)

Every week our team gets the privilege of sorting through our readers photos to choose what dogs will win this weeks contest! See...

Keep reading

Can Dogs Eat Bean Sprouts? Vet-Verified Benefits & Precautions

Bean sprouts make a great, crunchy topper for sandwiches or ramen, but can you share this healthy vegetable with the pet giving you the puppy dog eyes as you chow down on your meal? Yes, bean sprouts are generally safe...

Can Dogs Eat Bean Sprouts

How to Use Dog Food Toppers: Vet-Verified Facts & Types Explained

Dog food toppers can be an excellent way to spruce up your canine’s everyday meal. They can enhance the appetite of the pickiest pooches and add some calories if they’re needed. They can also soften dishes, making it easier for...

Dog waiting for the food

Do Dogs Need Carbohydrates? Vet Approved Facts & Advice

Carbohydrates are sugars, fibers, and starch. Strictly speaking, dogs technically do not need carbohydrates in their diet, but because carbs produce energy, they are beneficial when included in a dog’s balanced diet. This means you should ensure your dog eats...

Cute Samoyed dog eating from bowl at home

Can Dogs Eat Tamales? Vet-Verified Nutrition Facts & FAQ

Tamales are popular in Mexican cuisine, and people worldwide love to eat them. If you also love to eat tamales and have a dog, you’ve probably noticed your canine lurking around, looking for tamale scraps. Tamales are not suitable for...

Can Dogs Eat Tamales

10 Best Dog Foods for Hypothyroidism in 2025 — Reviews & Top Picks

A dog’s thyroid gland is located in their neck and has two lobes, one on each side of the trachea. The thyroid is responsible for regulating the body’s metabolism. Dogs with an overactive thyroid experience hyperthyroidism, and their metabolic rate...

dog rescue sad pixabay

Royal Canin Dog Food vs Hill’s Science Diet: 2025 Comparison, Pros & Cons

There are dozens of dog food brands, and each offers several varieties. This leads to many products to sort through, a great deal of research, and too much misinformation. You want the best food possible for your dog, but you...

Dogster_Dog Food Royal Canin vs Hill’s Science Diet

10 Best Dog Foods for Tear Stains in 2025 – Reviews & Top Picks

Your dog could have tear stains for many reasons, including food intolerances. According to the American Kennel Club, some dogs see a reduction in tear stains after changing diets, we recommend a switch to a high-quality, limited-ingredient dog food.1 Before...

Closeup of Poodle dog with white fur and red tear stains

Can Dogs Eat Corn Flakes? Vet-Approved Advice & Precautions

You wake up in the morning and enjoy a bowl of corn flakes for breakfast. While enjoying your breakfast, you notice your dog looking at you intently, begging to have a bite of whatever delicious food you’re eating. As a...

Can Dogs Eat_Corn Flakes