Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Great Dane Health Issues: 9 Common Problems to Watch For (Vet Answer)

Dogster_Health Problems of Great Dane

Part of getting a Great Dane is knowing that you’ll have to deal with a few extra health problems. They’re more susceptible to a lot of potential health issues, and we’ve highlighted nine of the most common for you to keep an eye out for here.

We’ve also highlighted the signs of each condition. If you suspect your dog has any of these problems, please reach out to their vet right away for further diagnosis and treatment options.

Dogster_Website dividers_v1_Jan 18 2024-03

The 9 Common Great Dane Health Issues to Watch For

1. Bloat

Purebred blue Great Dane looking bad after New Years celebrations
Image By: Guy J. Sagi, Shutterstock
Seriousness: Life-threatening
Signs: Pacing, pawing at the stomach, dry heaving, whining, shallow breathing, refusal to lay on their side, standing in a hunched position

Bloat, also known as gastric torsion, is a potentially life-threatening disease that often affects Great Danes. This condition happens when a Great Dane eats too quickly and gas rapidly expands inside their stomach.

This creates a lot of discomfort for them, and it can cause their stomach to twist at the top and bottom. This condition is life-threatening and will likely require surgery. If you suspect your Great Dane is suffering from bloat, you need to take them to a vet immediately. Also, keep in mind that a dog that suffers from bloat once is more likely to develop the condition again in the future.


2. Cardiomyopathy

Seriousness: Life-threatening
Signs: Lethargy, weight loss, weakness, difficulty breathing, decreased appetite, coughing

Cardiomyopathy is one of the most underdiagnosed conditions a Great Dane can have. It has a genetic and nutritional background. This condition causes the heart’s wall to stretch and weaken causing the heart to enlarge. Without proper treatment, it can be fatal to your dog, and often, the condition isn’t diagnosed until after the dog passes away.

Cardiomyopathy is a genetic condition of the Great Dane, and it’s one reason why you always want a full medical background and references from a breeder before purchasing a dog.


3. Tricuspid Valve Dysplasia

Owner with her Great dane at veterinary
Image By: hedgehog94, Shutterstock
Seriousness: Life-threatening
Signs: Distended stomach, trouble breathing, heart murmurs, trouble exercising, rapid heartbeat, weakness

Tricuspid valve dysplasia is an extremely serious condition that affects your dog’s heart. It is a congenital condition affecting one of the heart valves, and without proper treatment, it can kill your dog.

Dogs with tricuspid valve dysplasia might start accumulating fluid in the abdominal cavity. They will need to get diuretics, and, in severe cases, regular procedures to remove the excess fluid accumulation in their abdominal cavity. If your vet diagnoses your Great Dane with tricuspid valve disease, follow their instructions exactly to try and get the condition under control.


4. Joint & Bone Diseases

Seriousness: Ranges from mild to very serious
Signs: Whining, stiffness, reluctance to exercise, lethargy

Great Danes are especially susceptible to a wide range of bone and joint diseases because of their larger size. Sometimes the conditions are mild, and other times a Great Dane will need surgery to correct the condition.

If you notice your Great Dane is struggling to move around as much as they should, take them to a vet for further diagnosis and treatment.


5. Hip Dysplasia

ill dog lying on the floor during treatment
Image By: msgrafixx, Shutterstock
Seriousness: Very high
Signs: Lameness, stiff back legs, hopping while running, difficulty standing, pain when moving or exercising

Hip dysplasia is a joint problem that often shows up in larger dogs. And as the tallest dog in the world, the Great Dane certainly fits into this category. Hip dysplasia happens when one of the dog’s legs leaves the socket joint of the hip, creating a lot of pain and discomfort for the dog.

Sometimes the dog will be able to get the joint back in by themselves, but if it happens once, it’s more likely to happen again in the future. Typically, surgery is required to fix the condition.

hip dysplasia in dogs
You are free to use this image but we do require you to link back to Dogster.com for credit.

6. Hypothyroidism

Seriousness: High
Signs: Weight gain, lethargy, changes to skin/hair, and cold weather intolerance

Hypothyroidism is a condition that many dog breeds suffer from, and the Great Dane is no exception. Currently, there is no cure for hypothyroidism, but there are available treatment options.

Without treatment, hypothyroidism can cause excessive weight gain, lethargy, and even skin and ear infections. A vet will need to complete blood work to diagnose hypothyroidism, but once you have a diagnosis, they can prescribe medication to help with the signs.


7. Allergies

Dog hair loss dog allergy
Image By: Ri6ka, Shutterstock
Seriousness: Mild to serious
Signs: Sneezing, skin rashes or hives, watery/red/itchy eyes, coughing, nasal congestion

Allergies affect tons of dogs. Allergies can come from anything from food to environmental factors. If your Great Dane is suffering from allergies, you should take them to a vet where they can run a panel to determine exactly what your Great Dane is allergic to.

Allergies can range from red and itchy eyes to severe rashes hives or anything in between! But whether your dog is suffering from mild or severe allergies, we recommend taking them to a vet and getting them on the right treatment plan so they can be a bit more comfortable.


8. Wobbler Syndrome

Seriousness: Very serious
Signs: Wobbly gait, stiff neck, weakness, weak front limbs, trouble standing

Wobbler syndrome is one of the lesser-known diseases that can affect a Great Dane, but it’s still very serious. Wobbler syndrome, also called cervical spondylomyelopathy (CSM), is a spinal injury that occurs at the neck. It’s common among larger breeds, and treatment options for a dog with wobbler syndrome vary from bed rest and anti-inflammatories to surgery.

If you are concerned about the health and well-being of your pet, we recommend getting in touch with a vet for guidance.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's our online service where you can talk to a vet online and get the advice you need for your dog — all at an affordable price!

PangoVet_Mention-in-Content Savings V1


9. Cancer

Seriousness: Life-threatening
Signs: Lumps throughout the body, swelling, lameness, anorexia, joint or bone pain, lethargy

Cancer is a condition that affects many older dogs, and Great Danes are especially susceptible to osteosarcoma, also known as bone cancer. Unfortunately, unless you catch osteosarcoma early on it’s usually fatal.

Even worse, often by the time signs of osteosarcoma start to present it’s too late for effective treatment.

Grey Great Dane just as the sun is starting to set
Image By: Guy J. Sagi, Shutterstock

Dogster_Website dividers_v1_Jan 18 2024-03

Summary

Just because a Great Dane is susceptible to these conditions doesn’t mean they’ll develop any of them. Get your Great Dane from a reputable breeder, feed them a high-quality diet, and keep up with their exercise requirements and you can reduce the likelihood of them developing many of these health problems in the future.


Featured Image Credit: hedgehog94_Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.


How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Can Dogs Eat Soybeans? Vet-Verified Facts & FAQ

The answer to whether dogs can eat soybeans is complicated. While soybeans are not technically toxic to your dog, there are plenty of...

10 Best Dog Leashes in 2026 – Reviews & Top Picks

You’d think picking a dog leash would be straightforward enough; after all, they all do the same thing, right? Yes and no. While...

Do Dogs Need to Run? 8 Vet-Approved Tips

We see videos of dogs running on the beach, chasing one another in the yard, and jogging along a trail with their human....

How & What Do Beagles Hunt? 3 Common Types of Prey

Beagles are one of the most iconic hunting dogs in the world. They’re smart, friendly, and incredibly skilled hunters. So, what do Beagles...

More related

Is Dog Sledding Cruel? Ethics, Facts & FAQ

Dog sledding became popular during the gold rush in the late 1800s. The prospectors needed transportation to get into the wilderness; the only...

When Is National Rescue Dog Day in 2026 & What Is It?

National Rescue Dog Day is celebrated each year on May 20th. Its goal is to promote the adoption of dogs from shelters, rescue...

Cane Corso Great Pyrenees Mix: Info, Pictures, Care & More

Mixing the stout Cane Corso with the graceful Great Pyrenees results in a strong working dog that makes a great family pet. Their...

Purina Pro Plan vs Hill’s Science Diet Dog Food: 2026 Comparison, Pros & Cons

Purina and Hill are both large pet food companies that have been around for decades. They’ve grown in popularity over the years and...

Keep reading

Hill’s Science Diet vs Blue Buffalo Dog Food: 2026 Comparison, Pros & Cons

Dog food can seem like a never-ending brigade of decisions. There are endless dog food brands available, and each brand produces dozens of recipes. On the shelf, it can be challenging to discern which dog foods are worth buying. We...

Dogster_Dog Food Hill’s Science Diet VS Blue Buffalo

10 Best Turkey Dog Foods in 2026 – Reviews & Top Picks

Protein is an essential macronutrient that your dog needs to thrive. Unfortunately, not all dogs fare well on all types of protein sources1. It’s simple to find chicken or beef-based dog food options, but turkey or fish aren’t quite as...

Golden Retriever dog eating

What Is Ash in Dog Food? Vet Approved Facts & FAQ

If you’ve been checking out the nutritional label on your dog’s bag of food and your first thought was something along the lines of “What the…?!” when you spotted “ash” listed—you can stop worrying now. Dog food manufacturers are not...

Black Dachshund dog guarding and eating food

Can Dogs Eat Mint? Vet Approved Facts & FAQ

What do you think of when you think of mint? Fresh breath, spruced-up salads, smoothies, and mojitos. But have you ever wondered if your dog can have mint? Smelly dog breath is a common complaint, so is it okay to...

can dogs eat mint

Can Dogs Eat Cantaloupe? Vet-Approved Nutrition Facts

One of the best parts of summertime is sitting down to enjoy a juicy piece of cantaloupe. These tasty treats are a great way to cool down, have a healthy snack, and stifle your hunger at the same time. If...

Can Dogs Eat Cantaloupe

Essence Dog Food Review 2026: Recalls, Pros & Cons

Review Summary In today’s world, it can be hard to figure out which dog food brand is best for your pup. You love your dog and want the best for them. And you know that feeding them the best food...

Dogster_Essence Dog Food Review

Kirkland Signature Puppy Formula Dog Food Review 2026: Recalls, Pros & Cons

Stores that sell bulk items are a huge convenience, and Costco is one of the favorites. If you have a puppy, Costco’s brand of puppy food, Kirkland Signature Puppy Formula, is an excellent choice. You’ll be pleased to hear that...

Dogster_Kirkland Signature Puppy Formula Dog Food Review

8 Best Dog Foods for Hair Loss in 2026: Reviews & Top Picks

Shedding is common with some dog breeds, but if you experience more shedding than usual or hair coming out in clumps, leaving behind bald patches, that’s a sign that something is amiss. Whether your dog is suffering from a skin...

a shetland sheepdog shedding a lot