Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Great Dane Health Issues: 9 Common Problems to Watch For (Vet Answer)

Dogster_Health Problems of Great Dane

Part of getting a Great Dane is knowing that you’ll have to deal with a few extra health problems. They’re more susceptible to a lot of potential health issues, and we’ve highlighted nine of the most common for you to keep an eye out for here.

We’ve also highlighted the signs of each condition. If you suspect your dog has any of these problems, please reach out to their vet right away for further diagnosis and treatment options.

Dogster_Website dividers_v1_Jan 18 2024-03

The 9 Common Great Dane Health Issues to Watch For

1. Bloat

Purebred blue Great Dane looking bad after New Years celebrations
Image By: Guy J. Sagi, Shutterstock
Seriousness: Life-threatening
Signs: Pacing, pawing at the stomach, dry heaving, whining, shallow breathing, refusal to lay on their side, standing in a hunched position

Bloat, also known as gastric torsion, is a potentially life-threatening disease that often affects Great Danes. This condition happens when a Great Dane eats too quickly and gas rapidly expands inside their stomach.

This creates a lot of discomfort for them, and it can cause their stomach to twist at the top and bottom. This condition is life-threatening and will likely require surgery. If you suspect your Great Dane is suffering from bloat, you need to take them to a vet immediately. Also, keep in mind that a dog that suffers from bloat once is more likely to develop the condition again in the future.


2. Cardiomyopathy

Seriousness: Life-threatening
Signs: Lethargy, weight loss, weakness, difficulty breathing, decreased appetite, coughing

Cardiomyopathy is one of the most underdiagnosed conditions a Great Dane can have. It has a genetic and nutritional background. This condition causes the heart’s wall to stretch and weaken causing the heart to enlarge. Without proper treatment, it can be fatal to your dog, and often, the condition isn’t diagnosed until after the dog passes away.

Cardiomyopathy is a genetic condition of the Great Dane, and it’s one reason why you always want a full medical background and references from a breeder before purchasing a dog.


3. Tricuspid Valve Dysplasia

Owner with her Great dane at veterinary
Image By: hedgehog94, Shutterstock
Seriousness: Life-threatening
Signs: Distended stomach, trouble breathing, heart murmurs, trouble exercising, rapid heartbeat, weakness

Tricuspid valve dysplasia is an extremely serious condition that affects your dog’s heart. It is a congenital condition affecting one of the heart valves, and without proper treatment, it can kill your dog.

Dogs with tricuspid valve dysplasia might start accumulating fluid in the abdominal cavity. They will need to get diuretics, and, in severe cases, regular procedures to remove the excess fluid accumulation in their abdominal cavity. If your vet diagnoses your Great Dane with tricuspid valve disease, follow their instructions exactly to try and get the condition under control.


4. Joint & Bone Diseases

Seriousness: Ranges from mild to very serious
Signs: Whining, stiffness, reluctance to exercise, lethargy

Great Danes are especially susceptible to a wide range of bone and joint diseases because of their larger size. Sometimes the conditions are mild, and other times a Great Dane will need surgery to correct the condition.

If you notice your Great Dane is struggling to move around as much as they should, take them to a vet for further diagnosis and treatment.


5. Hip Dysplasia

ill dog lying on the floor during treatment
Image By: msgrafixx, Shutterstock
Seriousness: Very high
Signs: Lameness, stiff back legs, hopping while running, difficulty standing, pain when moving or exercising

Hip dysplasia is a joint problem that often shows up in larger dogs. And as the tallest dog in the world, the Great Dane certainly fits into this category. Hip dysplasia happens when one of the dog’s legs leaves the socket joint of the hip, creating a lot of pain and discomfort for the dog.

Sometimes the dog will be able to get the joint back in by themselves, but if it happens once, it’s more likely to happen again in the future. Typically, surgery is required to fix the condition.

hip dysplasia in dogs
You are free to use this image but we do require you to link back to Dogster.com for credit.

6. Hypothyroidism

Seriousness: High
Signs: Weight gain, lethargy, changes to skin/hair, and cold weather intolerance

Hypothyroidism is a condition that many dog breeds suffer from, and the Great Dane is no exception. Currently, there is no cure for hypothyroidism, but there are available treatment options.

Without treatment, hypothyroidism can cause excessive weight gain, lethargy, and even skin and ear infections. A vet will need to complete blood work to diagnose hypothyroidism, but once you have a diagnosis, they can prescribe medication to help with the signs.


7. Allergies

Dog hair loss dog allergy
Image By: Ri6ka, Shutterstock
Seriousness: Mild to serious
Signs: Sneezing, skin rashes or hives, watery/red/itchy eyes, coughing, nasal congestion

Allergies affect tons of dogs. Allergies can come from anything from food to environmental factors. If your Great Dane is suffering from allergies, you should take them to a vet where they can run a panel to determine exactly what your Great Dane is allergic to.

Allergies can range from red and itchy eyes to severe rashes hives or anything in between! But whether your dog is suffering from mild or severe allergies, we recommend taking them to a vet and getting them on the right treatment plan so they can be a bit more comfortable.


8. Wobbler Syndrome

Seriousness: Very serious
Signs: Wobbly gait, stiff neck, weakness, weak front limbs, trouble standing

Wobbler syndrome is one of the lesser-known diseases that can affect a Great Dane, but it’s still very serious. Wobbler syndrome, also called cervical spondylomyelopathy (CSM), is a spinal injury that occurs at the neck. It’s common among larger breeds, and treatment options for a dog with wobbler syndrome vary from bed rest and anti-inflammatories to surgery.

If you are concerned about the health and well-being of your pet, we recommend getting in touch with a vet for guidance.

Did you know you can talk to a vet online? Click on the image or button below to schedule a call: PangoVet_Mention-in-Content Savings V1



9. Cancer

Seriousness: Life-threatening
Signs: Lumps throughout the body, swelling, lameness, anorexia, joint or bone pain, lethargy

Cancer is a condition that affects many older dogs, and Great Danes are especially susceptible to osteosarcoma, also known as bone cancer. Unfortunately, unless you catch osteosarcoma early on it’s usually fatal.

Even worse, often by the time signs of osteosarcoma start to present it’s too late for effective treatment.

Grey Great Dane just as the sun is starting to set
Image By: Guy J. Sagi, Shutterstock

Dogster_Website dividers_v1_Jan 18 2024-03

Summary

Just because a Great Dane is susceptible to these conditions doesn’t mean they’ll develop any of them. Get your Great Dane from a reputable breeder, feed them a high-quality diet, and keep up with their exercise requirements and you can reduce the likelihood of them developing many of these health problems in the future.


Featured Image Credit: hedgehog94_Shutterstock

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

25 Most Popular Pets Statistics in the US: Updated in 2025

Note: This article’s statistics come from third-party sources and do not represent the opinions of this website. Pet domestication is probably one of...

Do Dogs Get Bored? 7 Vet-Reviewed Signs & What to Do About It

Most pet dogs seem to have easy lives when you think of it – they’re treated to lots of cuddles, playtime, walks and...

10 Best Slow Feeder Dog Bowls in 2025 – Reviews & Top Picks

Some dogs eat their food entirely too quickly, leading to abdominal discomfort to medical emergencies, like bloat (also known as gastric dilatation-volvulus) and...

How Much Exercise Does a Dog Need Every Day? Care Tips & Facts

When it comes to dog exercise, how much exercise does a dog need every day based on breed and age? How do you...

More related

Vapor Wake Dogs: What They Are & What They Do (Vet Reviewed)

While most of us think of dogs as being loving companions and members of the family, dogs were first domesticated to work with...

10 Great Off-Leash Dog Parks in Arlington, TX to Visit in 2025

Arlington, Texas, is a great place to visit, with many sights to see, but if you are a pet owner, you likely want...

Can Dogs Eat Eel? Vet-Approved Feeding Facts

Many dogs love fish, whether a fishy food formula or home-prepared salmon or herring. However, when it comes to less conventional types of...

8 Best Dog Health & Activity Trackers in 2025 – Reviews & Top Picks

When you find yourself looking at health and activity trackers for your pet, it may simply be because you’re trying to stay proactive...

Keep reading

Royal Canin Dog Food Review 2025 – Pros, Cons, Recalls & FAQ

Royal Canin is easily one of the most popular dog food brands out there. It produces many different recipes, including ones that are breed specific, so many dog owners are drawn to it. However, there are also negatives about this...

How to Choose a Dog Food: 5 Vet-Approved Tips & Advice

As crucial as it is for your pet’s health, picking the best dog food is rarely easy. Several exceptional products are available, but wading through the complicated labels, brand messages, and marketing tactics can leave even the savviest consumer confused...

young woman shopping for pet food

Can Dogs Eat Cookies? Vet-Reviewed Nutrition Facts & Info

Cookies are often the first food we reach for when we crave something sweet or need comfort. So, if you find yourself whipping up a batch of grandma’s chocolate chip cookies this week, you might wonder if you can give...

Oatmeal Cookies on a plate

Can Dogs Eat Turnips? Vet-Reviewed Facts & Safety Guide

Turnips are hardy root vegetables similar to parsnips and potatoes. Dogs can eat turnips in moderation; they can provide some health benefits and dietary fiber, and they are fine for your dog as long as it doesn’t suffer from thyroid...

Can Dogs Eat_Turnips

True Chews Dog Treats Review 2025: Pros, Cons, Recalls & FAQ

Review Summary True Chews dog treats are part of the Blue Buffalo line (though they weren’t always) and can be located in most pet stores and online, so you may be familiar with them. The brand offers a fairly good...

Dogster_True Chews Dog Treats Review

Is It Bad to Switch Dog Food Often? Vet-Reviewed Facts & FAQ

A mistake that many dog owners make is finding good dog food and sticking to it forever. In fact, that’s the advice that many people give—advice that may have even come from your parents when you adopted your first dog....

dalmatian dog eating dry food from a bowl

Can Dogs Eat Chayote? Vet-Verified Facts & FAQ

Chayote (or mirliton/choko) is a fruit that belongs to the gourd family and was first cultivated in Mexico and Honduras. These fruits are a great snack for dogs; they can eat them without any issues. Chayote is nutritious and versatile,...

Can Dogs Eat_chayote

10 Best Chicken & Rice Dog Foods in 2025 – Reviews & Top Picks

Chicken and rice recipes are among the most popular and common dog food formulas. Virtually every brand and formula offers a chicken and rice recipe, and for good reason! Chicken is a lean, healthy, complete protein that’s affordable and highly...

cream dog eating from the bowl