Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Great Dane Health Issues: 9 Common Problems to Watch For (Vet Answer)

Dogster_Health Problems of Great Dane

Part of getting a Great Dane is knowing that you’ll have to deal with a few extra health problems. They’re more susceptible to a lot of potential health issues, and we’ve highlighted nine of the most common for you to keep an eye out for here.

We’ve also highlighted the signs of each condition. If you suspect your dog has any of these problems, please reach out to their vet right away for further diagnosis and treatment options.

Dogster_Website dividers_v1_Jan 18 2024-03

The 9 Common Great Dane Health Issues to Watch For

1. Bloat

Purebred blue Great Dane looking bad after New Years celebrations
Image By: Guy J. Sagi, Shutterstock
Seriousness: Life-threatening
Signs: Pacing, pawing at the stomach, dry heaving, whining, shallow breathing, refusal to lay on their side, standing in a hunched position

Bloat, also known as gastric torsion, is a potentially life-threatening disease that often affects Great Danes. This condition happens when a Great Dane eats too quickly and gas rapidly expands inside their stomach.

This creates a lot of discomfort for them, and it can cause their stomach to twist at the top and bottom. This condition is life-threatening and will likely require surgery. If you suspect your Great Dane is suffering from bloat, you need to take them to a vet immediately. Also, keep in mind that a dog that suffers from bloat once is more likely to develop the condition again in the future.


2. Cardiomyopathy

Seriousness: Life-threatening
Signs: Lethargy, weight loss, weakness, difficulty breathing, decreased appetite, coughing

Cardiomyopathy is one of the most underdiagnosed conditions a Great Dane can have. It has a genetic and nutritional background. This condition causes the heart’s wall to stretch and weaken causing the heart to enlarge. Without proper treatment, it can be fatal to your dog, and often, the condition isn’t diagnosed until after the dog passes away.

Cardiomyopathy is a genetic condition of the Great Dane, and it’s one reason why you always want a full medical background and references from a breeder before purchasing a dog.


3. Tricuspid Valve Dysplasia

Owner with her Great dane at veterinary
Image By: hedgehog94, Shutterstock
Seriousness: Life-threatening
Signs: Distended stomach, trouble breathing, heart murmurs, trouble exercising, rapid heartbeat, weakness

Tricuspid valve dysplasia is an extremely serious condition that affects your dog’s heart. It is a congenital condition affecting one of the heart valves, and without proper treatment, it can kill your dog.

Dogs with tricuspid valve dysplasia might start accumulating fluid in the abdominal cavity. They will need to get diuretics, and, in severe cases, regular procedures to remove the excess fluid accumulation in their abdominal cavity. If your vet diagnoses your Great Dane with tricuspid valve disease, follow their instructions exactly to try and get the condition under control.


4. Joint & Bone Diseases

Seriousness: Ranges from mild to very serious
Signs: Whining, stiffness, reluctance to exercise, lethargy

Great Danes are especially susceptible to a wide range of bone and joint diseases because of their larger size. Sometimes the conditions are mild, and other times a Great Dane will need surgery to correct the condition.

If you notice your Great Dane is struggling to move around as much as they should, take them to a vet for further diagnosis and treatment.


5. Hip Dysplasia

ill dog lying on the floor during treatment
Image By: msgrafixx, Shutterstock
Seriousness: Very high
Signs: Lameness, stiff back legs, hopping while running, difficulty standing, pain when moving or exercising

Hip dysplasia is a joint problem that often shows up in larger dogs. And as the tallest dog in the world, the Great Dane certainly fits into this category. Hip dysplasia happens when one of the dog’s legs leaves the socket joint of the hip, creating a lot of pain and discomfort for the dog.

Sometimes the dog will be able to get the joint back in by themselves, but if it happens once, it’s more likely to happen again in the future. Typically, surgery is required to fix the condition.

hip dysplasia in dogs
You are free to use this image but we do require you to link back to Dogster.com for credit.

6. Hypothyroidism

Seriousness: High
Signs: Weight gain, lethargy, changes to skin/hair, and cold weather intolerance

Hypothyroidism is a condition that many dog breeds suffer from, and the Great Dane is no exception. Currently, there is no cure for hypothyroidism, but there are available treatment options.

Without treatment, hypothyroidism can cause excessive weight gain, lethargy, and even skin and ear infections. A vet will need to complete blood work to diagnose hypothyroidism, but once you have a diagnosis, they can prescribe medication to help with the signs.


7. Allergies

Dog hair loss dog allergy
Image By: Ri6ka, Shutterstock
Seriousness: Mild to serious
Signs: Sneezing, skin rashes or hives, watery/red/itchy eyes, coughing, nasal congestion

Allergies affect tons of dogs. Allergies can come from anything from food to environmental factors. If your Great Dane is suffering from allergies, you should take them to a vet where they can run a panel to determine exactly what your Great Dane is allergic to.

Allergies can range from red and itchy eyes to severe rashes hives or anything in between! But whether your dog is suffering from mild or severe allergies, we recommend taking them to a vet and getting them on the right treatment plan so they can be a bit more comfortable.


8. Wobbler Syndrome

Seriousness: Very serious
Signs: Wobbly gait, stiff neck, weakness, weak front limbs, trouble standing

Wobbler syndrome is one of the lesser-known diseases that can affect a Great Dane, but it’s still very serious. Wobbler syndrome, also called cervical spondylomyelopathy (CSM), is a spinal injury that occurs at the neck. It’s common among larger breeds, and treatment options for a dog with wobbler syndrome vary from bed rest and anti-inflammatories to surgery.

If you are concerned about the health and well-being of your pet, we recommend getting in touch with a vet for guidance.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's our online service where you can talk to a vet online and get the advice you need for your dog — all at an affordable price!

PangoVet_Mention-in-Content Savings V1


9. Cancer

Seriousness: Life-threatening
Signs: Lumps throughout the body, swelling, lameness, anorexia, joint or bone pain, lethargy

Cancer is a condition that affects many older dogs, and Great Danes are especially susceptible to osteosarcoma, also known as bone cancer. Unfortunately, unless you catch osteosarcoma early on it’s usually fatal.

Even worse, often by the time signs of osteosarcoma start to present it’s too late for effective treatment.

Grey Great Dane just as the sun is starting to set
Image By: Guy J. Sagi, Shutterstock

Dogster_Website dividers_v1_Jan 18 2024-03

Summary

Just because a Great Dane is susceptible to these conditions doesn’t mean they’ll develop any of them. Get your Great Dane from a reputable breeder, feed them a high-quality diet, and keep up with their exercise requirements and you can reduce the likelihood of them developing many of these health problems in the future.


Featured Image Credit: hedgehog94_Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.


How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Sighthounds: Breeds, Jobs & Facts (With Info & Pictures)

Sighthounds are impossible to miss thanks to their long, lean, muscular bodies. From Greyhounds to Afghan Hounds to Whippets, sighthounds are elegant dogs...

How to Rehome a Dog: 16 Vet-Approved Steps

Dog parents love their pets; there’s no two ways about it. But sometimes, life happens, and you need to rehome your dog for...

Phantom Cockapoo: Info, Pictures, Origin & History

Cockapoos are known worldwide for their friendly, even-tempered natures. They are always willing to play and are intelligent enough to be easily trained....

Belgian Shepherd Laekenois Dog Breed: Info, Pictures, Care & Traits

The Belgian Laekenois is one of the four herding dogs from Belgium. All these dogs are called “Belgian Shepherds,” but they are technically...

More related

How to Get Rid of Wet Dog Smell: 7 Easy Steps

Dogs make great companions, but they aren’t always our nose’s best friends. That’s especially true when they get wet. Wetness can liberate some...

190+ Belgian Malinois Dog Names: Popular & Unique Ideas

Congratulations on your brand-new Belgian Malinois! These confident, hard-working pups are known to form an intense and unbreakable bond with their humans, so...

Doxle (Dachshund & Beagle Mix): Info, Pictures, Care & More

A cross between a Dachshund and a Beagle, the Doxle is one of the cutest and most loving breeds you’ll find out there....

How Old Is a Puppy When Their Balls Drop? Our Vet Explains

The testes develop behind the kidneys in the abdomen while a puppy is still in the womb. In most puppies, the testes descend...

Keep reading

Purina Beneful Dog Food Review 2026: Pros, Cons, Recalls & FAQ

Review Summary Purina is one of the largest dog food manufacturers out there today. They were actually one of the first to create dry dog food and remain one of the most popular options today. In fact, the history of...

Dogster_Purina Beneful Dog Food Review

Can Dogs Eat Tater Tots? Vet-Approved Facts & FAQ

Chances are that you didn’t feed your dog tater tots on purpose, but if they got into a few that were left out, what should you do? Are tater tots toxic for dogs, and if you do have a few...

Can Dogs Eat_Tater Tots

Members Mark vs Kirkland Dog Food (2026 Comparison): Pros, Cons, and What to Choose

It is no secret that Americans love their dogs. In fact, according to the American Pet Products Association, 68% of US households include a pet—and that number is only growing. With so many people making pets a part of their...

Dogster_Dog Food Members Mark VS Kirkland

Can Dog Food Go Bad? Vet-Approved Facts & Tips to Preserve It

< Every dog owner has been in a situation where they buy bulk dog food to save money, trips to the grocery store, or time. Maybe you couldn’t power through that one open bag of dog food quite yet, or...

wet and dry dog food

Can Adult Dogs Eat Puppy Food? Vet-Approved Facts & FAQ

We all know that there is puppy food and adult dog food. If you are the proud owner of a new puppy, congratulations! But if you already have an adult dog in the home, you know that there’s potentially going...

Can Adult Dogs Eat Puppy Food

Can Dogs Eat Crunchy Peanut Butter? Vet-Verified Nutrition Facts & Info

Check with your veterinarian before adding any new foods to your pet’s diet, particularly if your pet has any underlying health conditions or is on a special diet. While the advice in this article has been fact checked and approved...

Dogster-Can-Dogs-Eat-Crunchy Peanut Butter

10 Best Blue Buffalo Dog Foods in 2026 – Reviews & Top Picks

These days, it’s pretty easy to know that your dog’s diet is one of the primary deciding factors in overall lifelong health. We recently had the opportunity to review all of Blue Buffalo’s recipe lines to see what they offer...

dog eating dog food

9 Best Dog Foods for Toy Poodles in 2026 – Reviews & Top Picks

The Toy Poodle is a small dog breed popular for its boisterous personality and fluffy, curly coat. These Poodles, like other toy breeds, are susceptible to digestive upset and require a diet that’s ideal for their sensitive stomachs. In addition,...

poodle dog eating