Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Can Vaccines Make Lymph Nodes Swell? Vet-Reviewed Health Facts

Share

veterinarian injecting a dog with vaccine

The stress level of taking your dog to the vet for their annual shots can depend on the situation and the individual dog. Some dogs are far more stressed about vet visits than others, and some dogs think going to the vet is just as fun as a trip to the park.

Regardless of where your dog falls on the spectrum, it can be stressful for you as a pet owner to bring your dog home after their shots, only to discover that they seem to have swollen lymph nodes. Is their vaccine the cause, though? And should you be concerned about this? In short, yes, vaccines may make your dog’s lymph nodes swell. Although this reaction is quite common, let’s explore what to do, especially when your dog has other distressing signs.

divider single dog paw oct 2024

Can Vaccines Make Lymph Nodes Swell?

Lymph nodes are small organs that contain immune cells. So, when your dog’s body gets invaded by bacteria or viruses, the lymph nodes may enlarge as they work to fight off the invader. Lymph nodes are an essential component of your dog’s immune system. Swelling of the lymph nodes after getting a vaccination is often a response brought on by the immune system reacting to the presence of the vaccine components, similar to the way they would react to a microbe.

Swollen lymph nodes can be a side effect of having vaccines. Side effects are not the same thing as allergies, though, so swollen lymph nodes after vaccines don’t necessarily mean that your dog is allergic to the shots they received. Side effects can be mild to severe when it comes to any vaccine or medication.

If you notice swollen lymph nodes after a vaccination, it’s probably best to give your vet a call and let them know, especially if they’re happening alongside other negative signs, such as vomiting, coughing, fever, lethargy, or poor appetite. If you notice swollen lymph nodes at any other time, be sure to contact your veterinarian.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's our online service where you can talk to a vet online and get the advice you need for your dog — all at an affordable price!

PangoVet_Mention-in-Content Savings V1

What if My Dog Has Swollen Areas Elsewhere?

Your dog has five sets of lymph nodes in their body, including the neck (submandibular), chest (prescapular), armpit (axillary), groin (inguinal), and knees (popliteal). Swelling can occur in any of these lymph nodes.

If your dog has swelling that is right near the area where they received their vaccine, then there’s a chance that they’re experiencing localized swelling from the shot.

Like lymph node swelling, swelling at the site of an injection is likely an inflammatory immune response to the introduction of a foreign substance. This swelling typically goes down on its own within 24–48 hours. If the swelling at the vaccine site does not begin to go down within a day or so, or if the swelling increases, the area becomes hot, or your dog is experiencing extreme tenderness, then you should have your vet check on your dog. There is a risk of infection with any type of injection, and it’s also possible for your dog to experience a more severe reaction.

Lymph node on brindle dog's leg
Image Credit: Pegasene, Shutterstock

What Should I Do if the Swelling Is Increasing?

If the swelling around your dog’s lymph nodes seems to be increasing, then they need to be seen by a veterinarian. If your dog is experiencing an increase in swelling shortly after the vaccine, then they may be having an allergic reaction.

Swelling of the face, tongue, or throat should be considered a medical emergency because it can rapidly lead to anaphylaxis and an inability to breathe. If you’re unsure if the swelling your dog is experiencing is something you should be concerned about, then don’t hesitate to call your vet or take your dog back to the clinic for a check-over.

male vet holding an old dachshund dog
Image Credit: Alice Rodnova, Shutterstock

divider dog paws 3 oct 2024

In Conclusion

Swollen lymph nodes can be a side effect of vaccines that indicates that your dog is experiencing an immune system response. There isn’t necessarily any reason to be concerned if this occurs, but significant swelling, swelling that lasts longer than 24 hours, or swelling that spreads to the throat, mouth, or face should be addressed by a veterinarian. When in doubt, it’s always best to give the vet a call, just to be safe.


Featured Image Credit: Oleg Kopyov, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.




How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Ask Dr. Paola- Help! My Dog’s Sleeping Habits Have Changed! (May 18, 2026)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

The Crate Setup Most Dog Owners Get Wrong (And How To Fix It!)

Most people assume that if their dog hates the crate, the crate is the problem. So they try a bigger one, a different...

1,500 Beagles Rescued from Wisconsin Lab Farm – Here’s Where They’re Going

You may remember that a few weeks ago, we reported on a tense situation at Ridglan Farms, Wisconsin, a facility infamous for housing...

Dogster’s Weekly Photo Contest Winners: Window Watchers (May 11, 2026)

Every week our team gets the privilege of sorting through our readers photos to choose what dogs will win this weeks contest! See...

More related

Why Does My Dog Poop in His Crate? 10 Vet-Verified Reasons & Solutions

If your dog spends time in a crate on a regular basis, you want it to be someplace that is clean, safe, and...

Rhodesian Ridgeback Beagle Mix: Info, Pictures, Temperament & Traits

If you’re in search of a loyal, intelligent, and strikingly beautiful companion, look no further than the Rhodesian Ridgeback Beagle. This unique hybrid...

My Senior Dog Is Panting & Shaking, What’s Wrong? (Vet Answer)

As a veterinarian, getting to the bottom of excessive shaking and panting in senior dogs can be difficult. As the owner of a...

Kennel Cough in Dogs: Vet Reviewed Causes, Signs & Treatment

As a pet owner, you expect your dog to get sick at some point during their lives, but some canine illnesses are more...

Keep reading

How Long Will Dog Food Last? Vet-Approved Facts & FAQ

This is an important question, particularly if you have multiple dogs or a giant breed or buy in bulk. Of course, how you answer this question also depends on the kind of food that you purchase. First, look at the...

woman feeding dog with dry food

Can Dogs Eat Rice Cakes? Vet-Verified Nutrition Facts & FAQ

Rice cakes are a very popular snack that is often used as a lower-calorie alternative to bread, crackers, and chips. Since we frequently find ourselves wondering what foods in our pantry are safe for our dogs to eat, it’s important...

Can Dogs Eat_Rice Cakes

Can Dogs Eat Crickets? Vet-Verified Facts & FAQ

Crickets are insects that belong to the Grylloidea family.1 They typically have long bodies, segmented legs, and large antennae. A tough exoskeleton covers their bodies and provides protection from predators. They can be found almost everywhere in the world except...

Can Dogs Eat_Crickets

TBHQ in Dog Food: Vet-Approved Feeding & Safety Facts

TBHQ, or tertiary butylhydroquinone, is likely an ingredient that you aren’t familiar with. This chemical additive is commonly used in pet foods to extend shelf life and keep the food from going rancid. You might be surprised to know that...

person pouring dog food to a bowl

Wellness Dog Food vs Blue Buffalo: Pros, Cons & What to Choose

One of the most frustrating moments as a pet parent is when you’re sitting there scratching your head over which food is better for your dog—especially when every brand claims to be the best! Two popular dog food brands vying...

Dogster_Dog Food Wellness VS Blue Buffalo

Can Dogs Eat Sweet Potato Fries? Vet-Verified Nutrition Facts & Better Options

If you’re coming to this article concerned and ready to call the vet—just know that sweet potato fries aren’t toxic for your dog. However, if they are already made into fries, and you haven’t just cut up a fresh, sweet...

Dogster-Can-Dogs-Eat-Sweet-Potato-Fries

Can Dogs Eat Marshmallows? Vet-Verified Risks & FAQ

Most pet parents love to spoil their furry friends with all kinds of treats, so if you and your family are eating tasty marshmallows, you’ll likely be tempted to give one to your dog. But would that be a good...

Can Dogs Eat Marshmallows

Can Dogs Eat Orange Chicken? Vet-Verified Facts & Better Alternatives

Dogs enjoy eating sweet and savory foods, and most won’t refuse a serving of chicken. It may seem like orange chicken is an ideal food for dogs, and dogs can develop a taste for it. However, it’s not recommended to...

Dogster-Can-Dogs-Eat-Orange Chicken

Love Dogs? So Do We! Join the Dogster Community

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.




Sign up for the Dogster Email Newsletter