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Can My Dog Overdose on Glucosamine? Vet-Reviewed Safety Facts

Written by: Lorre Luther

Last Updated on April 9, 2024 by Dogster Team

Can My Dog Overdose on Glucosamine? Vet-Reviewed Safety Facts


Dr. Lauren Demos  Photo


Dr. Lauren Demos

DVM (Veterinarian)

The information is current and up-to-date in accordance with the latest veterinarian research.

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Glucosamine is an amino sugar that’s commonly taken by humans and their canine companions to promote joint health. Evidence suggests it may decrease joint pain and help prevent further cartilage and joint deterioration in dogs and people, and many veterinarians recommend glucosamine supplementation as part of a holistic approach to treating canine arthritis and joint pain.

But what happens if your pet gets too much? It’s rare for dogs to overdose on glucosamine, but it does happen, usually when dogs get into supplements.1 And extremely high doses of glucosamine can be toxic2. But your dog will most likely be fine if they accidentally get an extra canine glucosamine tablet or two one day, although they may experience a bit of vomiting and diarrhea. But reach out to your veterinarian for guidance immediately if your dog ingests large quantities of the product.

Does Glucosamine Help Dogs?

Many veterinarians recommend glucosamine for senior dogs3 with joint pain. Evidence suggests it may effectively reduce joint pain, lower inflammation, and increase mobility in some dogs suffering from arthritis. It may also slow joint degeneration and possibly even support new cartilage growth.

Other supplements veterinarians often recommend for canine joint pain4 include chondroitin sulfate, omega-3 fatty acids, green-lipped mussels (GLM), and methylsulfonylmethane (MSM). GLM is packed full of omega-3 fatty acids, and MSM has both antioxidant and anti-inflammatory properties. MSM also helps speed toxin removal from cells and may reduce joint pain.

While glucosamine isn’t a cure for canine degenerative joint conditions like arthritis, it may improve your pet’s overall quality of life by reducing their pain and making it easier for them to stay active, which plays a critical role in keeping dogs healthy.

owner giving medicine in capsule to corgi dog
Image Credit: megaflopp, Shutterstock

Are There Canine-Specific Supplements?

Yes. Dogs should only be given canine-specific supplements, as human products often contain mixtures of several vitamins and nutrients. And some compounds regularly added to human multiproduct vitamin formulations, such as vitamin D5, can be toxic to dogs in the high doses required to meet human nutritional needs. Signs of vitamin D poisoning include decreased appetite, increased urination, and excessive drooling.

Veterinary supplements are made with the specific needs of dogs in mind. They often contain only one targeted nutrient and are usually produced in canine-appropriate dosages. Ask your veterinarian for guidance on selecting specific products. They’ll be able to help you determine the correct regime for your pet and point you in the direction of high-quality options.

But you may not need to purchase canine supplements to get your pet the nutritional joint support they need. Senior and joint health pet food often include all the glucosamine, chondroitin and omega-3 fatty acids dogs need to obtain results, particularly in the early stages of osteoarthritis.

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How Else Can I Improve My Dog’s Joint Health?

Weight control and exercise are fundamental to optimal canine joint health. Osteoarthritis is a degenerative condition involving the progressive wearing away of joint surfaces. Overweight dogs are particularly likely to develop the disease. Once canine joint problems begin, they’re often made worse by excess weight and lack of activity.

Corgi eating dog food
Image Credit: Paul’s Lady. Shutterstock

Weight Management

Ensuring your dog maintains a healthy weight reduces the likelihood they’ll develop serious joint problems later in life. Overweight dogs diagnosed with arthritis almost always benefit from dropping a few pounds to decrease the stress on their joints. Overweight dogs often aren’t interested in exercise, which lubricates and soothes joints.


Getting enough physical movement also helps keep your dog’s muscles nice and healthy, allowing them to get up and go without becoming easily fatigued. And it’s great for canine heart, joint, muscle, tendon, and ligament health.

Some breeds require far more exercise than others, with some extremely active dogs, such as boxers and huskies, often needing multiple hours of exercise per day to remain healthy. Tiny pets like chihuahuas are often fine with a few daily leisurely walks. But all dogs need exercise to stay mentally and physically fit. And this includes dogs who are slowing down due to arthritis.

Dogs suffering from degenerative joint disease usually do best when they stay active. But being active doesn’t mean these pets should engage in the same activities as before their joints started aching. Gentle walks and swimming are both fantastic choices for arthritic dogs as they provide the benefits of exercise without putting too much stress on your pet’s joints. Concentrate on low-impact activities, go slow, and take plenty of breaks if your pet needs them. Avoid doing things that encourage your dog to jump or make quick sharp turns.

veterinarian checking up of an australian shepherd dog at clinic
Image Credit: Ermolaev Alexander, Shutterstock

Alternative Therapies

Some dogs obtain pain relief through alternative modalities such as acupuncture and hydrotherapy. Physical therapy can often improve mobility and provide a bit of pain relief by strengthening the muscles, ligaments, and tendons that support your pet’s joints. Your veterinarian can provide guidance on the most effective way to use diet, exercise, supplementation, and other treatment options to manage your dog’s condition.


It’s pretty difficult for dogs to overdose on glucosamine, but it can happen, particularly if they consume large quantities of high-dose supplements. Many veterinarians recommend this powerful amino sugar for pets suffering from degenerative joint conditions as it often reduces pain and lowers inflammation. It’s generally considered safe for long-term use.

If you choose to supplement your pet’s diet, use canine-specific products, as they usually only contain one or two nutrients and are dosed appropriately for dogs. Many joint health and senior dog food formulations include inflammation-easing and pain-reducing nutrients such as glucosamine, omega-3 fatty acids, and chondroitin sulfate. Before adding glucosamine or special food to your dog’s diet, talk to your veterinarian to ensure it’s suitable for your pet.

Featured Image Credit: Creative Cat Studio, Shutterstock

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