Get

In Your Inbox

Dogster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Zinc Neuter for Dogs: What Is It, Risk & Ethics

Share

dog-vaccination-at-the-vet-clinic

Neutering is a word most everyone can immediately recognize, it means to sterilize a male animal. Everywhere you look, you see people advocating for spay and neuter programs to eliminate the burden of unwanted pregnancies to get a handle on homeless pets. Neutering is often associated with surgery, a recovery period, and a financial cost.

Surgical neutering can however be an emotive subject and you may find yourself looking for alternatives.

If you were looking for alternatives, you might have heard of zinc neutering. Zinc neutering was a non surgical form of neutering in which a compound containing zinc gluconate was injected into a dog’s testicles instead of the testicles being removed entirely. Zinc neutering is no longer an option for pet owners because the medication used for zinc neutering has been discontinued.

In this article, we aim to explain what zinc neutering was, why it was used, and any risks that were associated with the method that might explain why this procedure is no longer performed.

divider dog paws 4 oct 2024

How Did Zinc Neutering Work?

Zinc neutering, or zeutering, was a form of chemical castration for dogs. It involved injecting a compound known as zinc gluconate directly into the center of each testicle. The medication used for zinc neutering was called Zeuterin, but Zeuterin is no longer being manufactured and the procedure is no longer performed.

Zinc neutering was considered a less invasive procedure that made pet owners hopeful that their dogs would get a less painful experience than previously was possible with only surgical options. The entire concept was to create a more affordable, less invasive, but just as effective procedure that would reduce animal homelessness and limit surgery complications.

dog before injection at vet office
Image Credit: Ground Picture, Shutterstock

How Did Zinc Neutering Come About?

Most often, neutering a male dog is performed using a method called orchiectomy.

During a neuter surgery, the vet puts the dog under anesthesia and removes the dog’s testicles to prevent the ability to reproduce. This procedure is typically done from an external approach via the scrotum or prepuce skin. It is the most trusted method in vet offices and shelters all over.

Neutering is not as invasive as a female spay procedure, but many dog owners are still a little wary about the process of neutering because of the risks of surgery and pain to the dog.

Zinc neutering was developed as an alternative to traditional neutering, in order to give dog owners a way to have their dogs sterilized without them having to be put under anesthesia and without some of the risks associated with traditional neuter surgery.

Where Is Zinc Neutering Used?

Currently, zinc neutering is not used anywhere, as Zeuterin, the medication used for the procedure, is not available. It was used for a short time and had promising results. However, due to funding issues, it was discontinued. Ark Science gained FDA approval for the drug but could not gain proper funding or backing for the product.

divider dog paws 4 oct 2024

Advantages of Zinc Neutering

Zinc neutering did possess a few benefits over the traditional surgical neutering procedure.

Near Painlessness

Because the procedure was performed using an injection of Zeuterin into the dog’s testicles in order to sterilize them, the procedure was thought to be nearly painless, especially compared to a surgical procedure involving incision into the skin and underlying tissues. Despite involving an injection of medication directly through the scrotal skin and into the center of the testicle only around 6% of the dogs studied showed any signs of pain.

vet-giving-injection-to-dog
Image Credit: Leoschka, Shutterstock

No Need for Anesthesia

Again, because this procedure was performed with a simple injection, there was no need for the dog to undergo full anesthesia. Anesthesia does have its risks, and not all dogs are good candidates for anesthesia. So, zinc neutering might have been an option for dog owners that were wary of anesthesia and due to underlying health problems. Some of the treated dogs were given a reversible sedation and others had the injection with no sedation.

Quicker Recovery Times

Although most male dogs don’t have to stay overnight at the vet’s office after a neutering procedure, it can still take them around a week to recover from the surgery. But with zinc neutering, the recovery time would have been reduced drastically as most dogs had no signs the zinc neutering had been done after 48 hours.

Less Invasive Procedure

And as we’ve mentioned, zinc neutering would have been a less invasive procedure compared to a traditional neuter. Although neutering is done externally, it still requires incisions to be made, but Zeuterin was administered via a simple injection into each testicle.

divider dog paws 4 oct 2024

Disadvantages of Zinc Neutering

However, as with any medical procedure, zinc neutering was not without risks. That led to some people being opposed to the procedure, just as there are people that are opposed to traditional neutering.

Unavailability

One of the disadvantages of zinc neutering was its unavailability, which is one of the main reasons that it is no longer used. Not all vet offices would have had access to it, and it may have even been more expensive due to its limited availability.

dog owner talking to vet
Image Credit: SeventyFour, Shutterstock

Limited Research

Unfortunately, because its use was fairly limited and there was a lack of funding despite FDA approval of Zeuterin, there was not sufficient long-term research as to how safe zinc neutering was and whether the benefits outweigh the risks. Without in-depth and extensive research, there would have been no way to determine how effective the procedure was, especially when compared to traditional neutering that has been performed successfully for decades and has been shown to be effective at sterilizing dogs.

Required Specialized Training

With zinc neutering, injection placement is everything. Zeuterin had to be placed in a precise location to be effective, so performing the injection takes special training on the veterinarian’s part.

Complications

Although small numbers of dogs were studied (270) some complications were seen such as swelling of the testes, scrotal skin ulceration and testicle abscess formation.

Testosterone Remains

Traditional neutering procedures remove the testicles, thus removing testosterone as well. For most dogs, testosterone can be the reason behind many unwanted behavioral related problems, such as wandering and, of course, sexual behaviors. With zinc neutering, testosterone levels may drop but don’t fall to zero, so some of those unwanted behaviors may remain.

two dogs mating outdoor
Image Credit: atiger, Shutterstock

divider dog paws 4 oct 2024

Frequently Asked Questions

Is zeutering less painful than surgically neutering an animal?

With the limited amount of research that was performed, most dogs seemed to show no visible signs of pain or discomfort. However, not a lot of studies were completed before the method was pulled from shelves.

Will Zeuterin ever be available again in the future?

Zeuterin was discontinued in 2016. While Zeuterin may not be available again, that doesn’t mean that another well-researched method that is similar won’t pop up eventually. With advancements in science, we get closer to making this experience as painless for our pups as we can.

How could zeutering change the way we perform sterilization in the future?

While Zeuterin might not have rolled out the way the company hoped, it might have sparked some new plans for the future. It at least gave a window into a more painless, less invasive way to neuter pets.

Husky dog lying on vet table with doctor and master near by
Image Credit: Pressmaster, Shutterstock

divider dog paws 4 oct 2024

The Importance of Neutering

Despite zinc neutering not currently being an option for our pets, neutering (and spaying for females) is still a very important decision that you need to make. Here are some pretty hefty statistics for you when it comes to spay and neuter surgery as well as pet homelessness.

  • Around 3 million animals are put into shelters each year. Some were abandoned, others surrendered, and others were picked up or brought in by dog wardens or concerned citizens.
  • Many pets that come into shelters aren’t spayed or neutered, meaning they could potentially reproduce at any time.
  • Approximately 390,000 dogs entering shelters are killed each year.

With these few statistics alone, it is easy to see what an epidemic this is. Animals are killed every year due to overpopulation and lack of resources.

divider dog paws 4 oct 2024

Conclusion

Now you know what the process of zinc neutering was like when it was available. It is currently discontinued, and there are no rumors or plans of bringing it back to the market anytime soon. However, with the way science develops, a new, improved method might be available soon.

As always, check any downfalls and potential risks of new medical procedures to keep your pets safe!


Featured Image Credit: FamVeld, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything dog

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.




How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Dogster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Dogster’s Weekly Photo Contest Winners: My Best Trick (April 16, 2026)

Every week our team gets the privilege of sorting through our readers photos to choose what dogs will win this weeks contest! See...

From Grief to Gratitude: How One “Potato” and a Road Trip Changed Everything

The “COVID Puppy” phenomenon is a well-known chapter of the pandemic, but for Alexis Walling, the arrival of a tiny, wrinkled English Bulldog...

Why Dogs Play Too Rough — And the Simple Fixes That Prevent It From Becoming a Problem

A dog that plays too rough with others is a problem that builds fast. One minute, the dogs are running and chasing, the...

Ricky Gervais Says: It’s Time to Release The Dogs

As activists prepare to carry out the biggest Open Rescue in the history of animal welfare, Ricky Gervais says, “it’s time to release...

More related

Can Dogs Have Persimmons? Vet-Verified Nutrition Facts & FAQ

Persimmons make a versatile addition to the kitchen and infuse foods with a delightful sweetness and unique health benefits that parents, kids, and...

Is Your Dog an Introvert? 10 Ways You Can Tell (Vet-Reviewed)

Are you an introvert or an extrovert? If you’re an introvert, you know how quickly social batteries can drain and how long it...

11 Best Podcasts About Dogs (2026 Guide)

Owning dogs can be an absolute joy, but it can also be challenging. Thankfully, with access to the Internet, owners can also enjoy...

What Is Meat Meal in Dog Food? Vet-Approved Facts & FAQ

There are many misconceptions about meat meal out there. Since meat meal isn’t whole meat, many dog owners assume that it’s a derivative...

Keep reading

Emergency Dog Food: What To Keep In a Survival Kit

Disasters are unpredictable, and the safety of our beloved canine companions is paramount during these critical times. Thankfully, preparedness goes a long way in ensuring the well-being of our furry friends. So, if you’re wondering what to put in a...

pug dog eating from feeding bowl

Can Dogs Eat Pears? Vet-Approved Facts & FAQ

It’s natural to wonder what foods are safe for your dog to consume, as it’s common to want to toss them a quick piece of meat or veggies while you’re at the dinner table. But what about fruit? More specifically,...

Can Dogs Eat Pears

10 Best Dog Foods for Border Collies in 2026 – Reviews & Top Picks

The food that you, as a pet owner, feed your dog is one of the most important aspects of keeping your pet healthy. If you own a Border Collie, then you know how high their energy and activity levels can...

Border collie holding food bowl

KetoNatural Dog Food Review 2026: Our Expert’s Opinion

As dog owners, we all want what’s best for our pets. That includes feeding them only the best, high-quality food. But with so many different dog foods out there, how do we know which one is best? The best and...

Dogster_KetoNatural Dog Food Review

Veritas Farms CBD Pet Chews Review 2026: Our Expert’s Opinion

Review Summary These full-spectrum hemp oil chews by Veritas Farms will help your pet slip into relaxation while they’re enjoying a tasty treat. The CBD Calming Chew is a must-have for a road trip with your dog if they have...

Veritas Farms CBD Pet Chews

Can a Human Eat Dog Food? Vet-Approved Facts & FAQ

If you’re thinking about eating dog food because you’re out of options, we have some bad news for you. Dog food is not meant for human consumption. It’s made with different ingredients and in different proportions than what we need...

Can a Human Eat Dog Food

13 Best Dry Dog Foods in the UK of 2026 – Reviews & Top Picks

When it comes to keeping your dog healthy, high-quality food is a must. Dry food, in particular, can play an important role in your pet’s diet. This popular choice offers several benefits, including helping to keep your companion’s teeth healthy...

dog with a food bowl

Can Dogs Eat Oatmeal Cookies? Vet-Verified Nutrition Facts & Info

For humans, oatmeal cookies are generally considered a healthier alternative to other cookies because they contain whole-grain oats, which are high in fiber, however, oatmeal cookies will still contain sugar and butter which are not healthy for dogs. Oatmeal cookies...

Dogster-Can-Dogs-Eat-Oatmeal Cookies

Love Dogs? So Do We! Join the Dogster Community

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.




Sign up for the Dogster Email Newsletter