First vaccines are usually given between 6 and 8 weeks for Parvo/ Distemper/ Parainfluenza, etc. Hopefully the mom was up to date prior to giving birth, as her immunity should help cover the pups up to this point, but be very careful, as they are very susceptible to Parvo! Some people think the vaccines they can mail order or buy at farm supply stores are good, but it is not worth it! Take the pups to the vet, the vaccines they use are superior to the others, have been shipped and stored at the right temperature to ensure efficacy, and if the pup were to have an immediate reaction, they can help, as opposed to dying at home before you can get help for it. Doing them at home is just plain dangerous! Plus, the doc will do a physical exam to check them out, and be certain they are healthy with no congenital birth defects.