|Barked: Fri Jun 10, '11 8:51am PST |
To determine whether dogs given garlic extract developed hemolytic anemia and to establish the hematologic characteristics induced experimentally by intragastric administration of garlic extract.
8 healthy adult mixed-breed dogs.
4 dogs were given 1.25 ml of garlic extract/kg of body weight (5 g of whole garlic/kg) intragastrically once a day for 7 days. The remaining 4 control dogs received water instead of garlic extract. Complete blood counts were performed, and methemoglobin and erythrocyte-reduced glutathione concentrations, percentage of erythrocytes with Heinz bodies, and percentage of eccentrocytes were determined before and for 30 days after administration of the first dose of garlic extract. Ultrastructural analysis of eccentrocytes was performed.
Compared with initial values, erythrocyte count, Hct, and hemoglobin concentration decreased to a minimum value on days 9 to 11 in dogs given garlic extract. Heinz body formation, an increase in erythrocyte-reduced glutathione concentration, and eccentrocytes were also detected in these dogs. However, no dog developed hemolytic anemia.
CONCLUSIONS AND CLINICAL RELEVANCE:
The constituents of garlic have the potential to oxidize erythrocyte membranes and hemoglobin, inducing hemolysis associated with the appearance of eccentrocytes in dogs. Thus, foods containing garlic should not be fed to dogs. Eccentrocytosis appears to be a major diagnostic feature of garlic-induced hemolysis in dogs."
I just weighed a large fresh garlic clove, 7 grams. If Max ate 12 of those cloves he would show signs in blood tests in a couple weeks it looks like. If he was using one of the other chemicals that also affects the blood cells he would probably be in trouble.
From the website posted by Aubrey,
"There is no doubt that onion, due to its concentration of thiosulphate, will cause Heinz factor anemia. In addition, as stated by Wendy Wallner, DVM, “Onions are only one of the substances which can cause Heinz body anemia. Other substances such as Acetaminophen (Tylenol) and benzocaine-containing topical preparations can also cause Heinz body anemia in the dog.” The latter probably accounts for many cases as it is prevalent in creams often recommended for allergy-suffering pets due to its ability to numb the itch. It is absorbed through the skin and builds up in the blood stream. This other substance is likely to have been involved in cases where garlic was suspect."
"Garlic is a favorite herb used by many pet owners to control fleas, ticks, mosquitoes, and other insects. While many of my clients swear by the ability of garlic to control fleas, and while I have no problem recommending its use, controlled studies have shown garlic to be ineffective as an insecticide. Garlic also has show antimicrobial and anti-cancer properties. Garlic can cause anemia in dogs and cats due to the presence of S-methyl cysteine sulfoxide and N-propyldisulfhide. Therefore, it should not be used in pets with anemia. As a general guideline, 1 clove of garlic per 10 pounds of body weight for dogs (and 1/2 clove per cat) can usually be fed safely each day. If you use garlic regularly (as a general food supplement,) it would be wise to have your pet's blood checked every few months to make sure anemia is not occurring. "
I am not going to give Max garlic supplements. What other substances in combination with garlic, Acetaminophen and benzocaine will also damage his blood?
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