|Barked: Sun Sep 5, '10 9:41am PST |
|Sabrina: The correct link is linked in my first post (three down from the original post)
Fritz: It was thought for many years that dogs don't actually suffer from strokes the same way humans do. Many times ODVD (old dog vestibular disease) was misdiagnosed or misrepresented as a stroke so people assumed that "real" strokes were not possible in dogs. Recent medical break throughs have proved that dogs are capable of having a "real" stroke.
ODVD symptoms are severe head tilt, circling, facial paralysis, inability to stand, ataxia (unsteady gait) and severe naseau. This disease is due to a problem with the dogs vestibular (inner ear or balance center).
A stroke is defined by an interuption of blood supply to any part of the brain. It can be caused by clots or sometimes by heamorghing blood vessels causing blood to pool around brain instead of entering brain. The type of stroke PPA is thought to cause in people in hemorrhagic stroke. This is the type of stroke that occurs when you bleed into your brain. The risk is very low and was only associated in increasing this type of stroke in 18-49 yr olds NOT in anyone else. Also the women in this study were taking PPA as an appetite suppresant (diet pill). The dose of PPA in those medications is almost 3x what is present in the PPA we use on our animals for sphyncter control. This may or may not be reason enough for us NOT to see strokes as commonly in animals.
In dogs we see strokes or what we usually call cerebro vascular accident (CVA) or a transient ischemic attack (TIA). They can lead to irreversible brain damage. Strokes are either caused by head injury (fall, HBC, other trauma), bleeding into the brain (usually from a clotting disorder or ruptured vessels), or from lack of blood or oxygen in the brain (this can be from trauma like choking or stranguling or from being drown or losing conciousness).
In the case of PPA we can assume the stroke is caused by the burst blood vessels which is what was seen in humans.
Symptoms of this type of stroke are facial paraylisis, blind in one eye, head tilt, collapse, lethargy, "senile" type symptoms and death.
In my best medical opinion I just don't see this PPA risk being one to lose to much sleep over. There have been no studies linking this risk to animals and the dosing is different than in the human studies.
At this point each patients risk should be weighed against the benefits of the medication. Strokes are very very rare in dogs and usually trauma or medically (diabetes, heart disease) induced NOT medication induced.
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