Bullmastiff as lump on side of leg

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Barked: Sat Dec 29, '12 6:39am PST 
hi my 4 year old bm as a lump on the side of her leg.. been to vets.. x rays= all clear.. bone biopsy= all clear.. they then sent her to the dogs hospital. wear they did 2 bone biopsy.. as they never dug deep enough the 1st time... results are clear. they what to do a forth bone biopsy in january as they do not know what is the problem. i am giving her metacalm for the pain.. can enyone pleas help me or have eny exp in this.. my dog is very actiff and full of life. the vet at the hospital told me.. that the head vet. as said it is defo a tumer but they havent found it.. pleas help....