January 14th 2014 8:42 pm
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For all the goodwill and love, to our pals.. Thank you for the gifts on our pack's behalf and in support of DOGster on a special anniFURsary for them.
They do good work. We wish we had more time to partake in the fun and festivities.
Once again, we thank Dogster and our pals for including Angel Mica, Mirra and the Purple Girls of Oregon, in this. Many of you are very special to us.
December 19th 2013 11:43 am
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Mirra just had her annual. We feel very fortunate, and are so blessed she passed with flying colors..
We'd like to recommend a few things..
Don't forget to brush your furry kids teeth on a daily basis. It's just so good for them and helps them be as well as they can be.
Then, there is this subject..
Yes they do wonders, but there are limits.. Mirra Has not been vaccinated now since 2009..we have her blood tested for immunity. It is known as TITERS.
Her Titers show full immunity..
We don't get why some vets push our pals to be revaccinated.. Ad nauseum..
It may be cheap to get the shots, but the costs to your loved ones health could be more than the dollars and cents saved.
Look into titers kids. Mirra's show sound immunity at close to five years..
At least do some reading on the subject, please.
We wish our pals every blessing and good health and a loving home..
We still do the work of our Angel, Mica the wonderpup, doing battle with IMHA, as are many dogs, cats and people. We so desperately need a cure.
Help us help others when you can.
May 30th 2013 8:37 pm
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To all of my pals, my Aunts, Uncles, and Cousins.. Whether they be dog, cat or human.. And especially ALL of the wonderful and LOVING ANGELS that watch over me.. Thank you FUR remembering me on my birthday.
It meant a great deal to me and of course mom. My good friend Chester even came by to spend some time with me. He is an 18 yr old cat who thinks he is a dog. We had a blast playing my favorite games ( we had a windy afternoon of Frisbee, which mom says makes me run extra fast), and the few sprinkles we received assured me of good luck! It is good luck when it rains on your birthday! We just came in from our third round of merriment. We don't know why, but I am simply mad about brand new gallon plastic jugs. Especially at night outdoors. Maybe it is genetic. Both mom and I are gonna sleep like logs!
I was sung to, in English and Italian, by two different loved ones, and received many nice surprises. By executive order there was no brushing today! They do NOT call me Rebel Force for nothing! My dad called.. He had to travel today ;(
I know he will deFURnitely make it up to me.
And so did McKenna. I am pooped and soon it will be bedtime. My beauty sleep is important, even tho I am still quite the spring chicken. I just wanted to say thanks to all the ones I love for making me feel special today. With EXTRA special thanks to Mica and ALL of the Angels who are the best.
Give all of my pals a big kiss & hug and tell them how much they mean to you (and me)!
We eat that stuff up!
Mirra, now six years young
May 1st 2013 10:06 am
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We like this and also know several dogs who have been using this effectively. It's ONE more sign of HOPE.. We hope and PRAY. With special KUDOS to our friend Guillermo Cuoto, who is a favorite IMHA researcher of ours, mentioned in this piece too. God Bless you..
Ad no, we cannot make any guarantees, nor do we stand to benefit from posting this. We hold no stock or financial interest of any kind. We just want our FURRY friends to be healthy and HERE..
Mel, Mirra & Angel Mica, aka the Purple Girls of Oregon, and the Girls of May..
THIS ONE IS FUR YOU UNCLE ANGUS..
SUMMARY of artemisinin
Artemisinin is an herb that helps kill cancer cells in the body. It may be used in conjunction with chemotherapy. It may be used before radiation treatments, but should be discontinued when starting radiation therapy, and not resumed until two months after the last radiation treatment. Dosages for each individual dog are usually determined by the owner with the help of his or her veterinarian, oncologist, or by consulting one of the sources at the end of this article. It is given away from food or supplements containing iron, and is cycled, that is given for a number of days, and then not given for a number of days. It has been used for years as an anti-malarial drug, and does not have toxic side effects at the doses recommended. It may decrease the effectiveness of seizure medication. One should monitor blood chemistry, kidney and liver enzymes, while on this drug, as with most other medications.
More information, including suppliers and researchers willing to consult about the drug with you or your veterinary practitioner are in the following article.
WHAT IS ARTEMISININ
Artemisinin is an herbal drug that has been shown to kill human and canine cancer cells in the laboratory. It is also being used to treat people and dogs with cancer.
It has been an effective anti-malarial drug in Asia for decades, so there is long standing knowledge about its effects and side effects. It works because the malaria parasite collects iron from the blood and stores it. The Artemisinin converts the collected iron into a chemical that releases a free radical, which then kills the malaria parasite.
It is one of four compounds derived from the herb Artemisia annua L., also known as sweet wormwood, annual wormwood, or sweet Annie. (It is not the same plant as perennial wormwood.)
HOW DOES IT WORK ON CANCER?
Cancer cells also collect and store iron because they need extra iron to replicate DNA when they divide. Therefore, the cancer cells have a higher concentration of iron than normal cells, and can be differentiated from normal cells. Two researchers at the University of Washington in Seattle, Professors Henry Lai, PhD and Narendra Singh, MBBS, began to study the use of Artemisinin in human patients. Then, in l999, working with a vet, they began to study its use in dogs with cancer.
Their experience has confirmed that Artemisinin helps stop the growth of cancer cells in dogs. Numerous anecdotal reports from people using Artemisinin for dogs with osteosarcoma, lymphoma, and metastases from osteosarcoma claim that it has extended their dogs lives beyond what was expected.
Artemisinin has two derivatives: Artesunate, which has a relatively short half-life; and Artemether, which may be a more effective derivative, because it stays in the body longer. It also may be more effective than Artemisinin alone in brain cancers, because it penetrates the blood-brain barrier more readily.
A product called Artemix is available from Wellcare Pharmaceuticals. It contains Artesunate, Artemether, and Artemisinin. The combination capsule may be more effective than Artemisinin alone.
HOW TO GIVE ARTEMISININ:
The optimal treatment regimen has still to be determined, and researchers are conducting trials to determine the best combination of derivative form, dosage and timing. In the meantime, the following protocols have been recommended.
Dosage: Initially, Dr Lai recommended a dose of 2.2-4.4mg of Artemisinin per pound of bodyweight. More recently, he has said that it may be preferable to use only Artemether and give it two times a day, 12 hours apart, keeping some in the blood stream at all times.
Dr.Singh believes taking all three forms of Artemisinin at the same time (bedtime) once a day is the most effective treatment protocol.
Dr. Cuoto recommends 6.6-8.8mg Artemisinin per pound.
Holley Pharmaceuticals is recommending up to 11-16mg Artemisinin per pound.
(For kilogram dosages, multiply the dose per pound by 2.2)
Timing: Again, there is some variation in timing. Some people split the dose, giving some in the morning and some before bed. Some give it all just before bed.
There is agreement that Artemisinin should not be given within 3 hours of food containing iron – for example, meat. It may also be better given away from anti-oxidants since it works by creating free radicals that attack the cancer cells, and anti-oxidants are harmful to free radicals.
Giving it with some fat is recommended, but not necessary. Many people disguise the capsules in cream cheese or other dairy product, or peanut butter. If your dog won’t take capsules, it may be emptied into whipped cream or other non-iron containing food. (It is quite bitter tasting.)
Cycling: Herbal remedies are thought to be more effective if they are “cycled” or “pulsed”, that is, given for a certain number of days, and then not given for a certain number of days. It is believed that if the body rests between doses, it will be less likely to build up a resistance to the herb, which will then be more effective for a longer period of time. Artemisinin may be cycled or pulsed by days or weeks.
Examples: One protocol for a 70-pound dog with OS consists of a 100 mg capsule of Artemisinin (Art-E) in the morning, and a capsule of Artemix before bed. This course is followed for two weeks on and then one week off.
A 60-pound dog is given 200mg of Artemisinin in the morning, and 40 mg of Artemether in the evening, 5 days on and 2 days off.
Another dog has been given mega doses one day per week.
Each person needs to determine the amount and frequency of giving Artemisinin and its derivatives to his or her dog, taking into account how the dog responds to the treatment, and other factors. Your holistic or conventional veterinarian or oncologist may be willing to help you with this. (There is contact information in the resources at the end of this article for further individual help, either through email to Dr Lai or Dr Cuoto, or through the BCD members or the Artemisinin yahoo group members.)
When Artemisinin was tested with monkeys, they showed no toxicity after they received up to 292 mg/kg (642 mg/pound) of Artemether over 1 to 3 months.
Animal research has shown neurotoxic results with massive doses of Artemether—150mg/kg/day (330mg/pound).
Generally, at the lower recommended doses of 2-16 mg/pound, there is no reported toxicity.
It is recommended that kidney and liver enzyme levels be monitored though out your dog’s treatment with Artemisinin or other herbal or alternative therapies.
Reported (Oral): Artemisia may cause abdominal pain, bradycardia, diarrhea, nausea, vomiting, decreased appetite, flu-like symptoms, fever, and decreased reticulocyte count. (Bradycardia is a resting heart rate of 60 beats or less.)
(BCD: One assumes these oral reports were from humans!)
Radiation releases iron stored in cancer cells into surrounding tissue. Therefore, it is recommended that it be used before radiation treatments, be discontinued during radiation treatments, and not resumed until two months after the last radiation treatment.
Artemisinin was tested in combination with 22 chemotherapy drugs and was found to enhance the drugs’ effectiveness. If used in conjunction with chemotherapy, it should be taken several hours after the chemotherapy treatment ends. (Artemisinin does not alleviate possible chemotherapy side effects.)
Butyrex or Butyrin
May increase the effectiveness of Artemisinin, but there is no certainty of this.
Professor Narenda Singh, MBBS is reported to have developed an instruction page for physicians considering intramuscular injections of Artesunate.
ARTEMISININ PRODUCTS ARE AVAILABLE FROM:
Holley Pharmaceuticals 1-866-846-5539, 714-871-7070
Wellcare Pharmaceuticals 1-877-728-2073
International: A person in Germany was able to reach an International Pharmacy that ordered Artemisinin from: Nutricology
Make sure the Artemisinin product you buy comes from a source that certifies the strength of the dose as there is wide variation in the amount of Artemisinin collected from plant to plant.
As with other complementary or alternative therapies, Artemisinin’s effectiveness is enhanced by a good diet, high in protein and low in carbohydrates. (See files.)
Antioxidants help to clear the body of the waste from Artemisinin’s action on cancer cells. Dr. Singh recommends Vitamin C for its anti-cancer properties, but does not recommend glutathione, which may reduce the efficacy of Artemisinin.
Antacids: Artemisia interferes with antacids, sucralfate, proton pump inhibitors, and histamine-receptor antagonists because it increases the production of stomach acid.
(BCD Note: Many OS dogs are on some form of over-the counter antacid for other medications they are on. You might want to add one if your dog exhibits gastrointestinal symptoms when taking Artemisinin, or if the drug is less effective while the dog is on it. Pepcid AC is well tolerated.)
According to Dr Lai, after long term use at high doses, Artemisinin increases an enzyme in the body that makes some anti-seizure drugs less effective. He recommends increasing the dose of the anti-seizure drug, if possible, or stopping Artemisinin for several days, and the enzyme levels will return to normal.
(BCD Note: One person using Artemisinin for her seizure grey reports no ill effects from the herb. Consult with your vet if your dog is prone to seizures.)
Dr. Lai; Professor; 206-543-1071; Email: firstname.lastname@example.org
Questions About Artemisinin: (Dr. Lai’s group); Email: email@example.com
Dr. Singh; Professor; 206 685 2060; Email: Narendra@u.washington.edu
University of Washing Link to research articles http://depts.washington.edu/bioe/about/news/artemisinin/arte misinin.html
Dr. Cuoto; Veterinarian (Conducting Artemisinin study at Ohio State University, and a friend of Greyhounds); Email: firstname.lastname@example.org
Yahoo Artemisinin_and_Cancer Support Group
Information about a clinical trial at Ohio State –not necessarily in effect currently, but one might inquire.
Whole Dog Journal;New Hope for Treating Cancer, May 2003
Dr. Singh’s recommendations:
Keep a record of the animal’s weight, before and during therapy;
Diagnostic x-ray or biopsy before and after two months of treatment;
Measurements of maximum and minimum tumor sizes before and after 2 months of therapy;
Observe for fever on 2nd or 3rd day and make a note to give enough water during the night;
Keep Artemisinin in dark, indirect light, and keep in cold – 4 degrees centigrade, or 37 degrees Fahrenheit.
Avoid iron-rich foods such as meat 3 to 4 hours before Artemisinin dose. Make sure dog has an adequate supply of vitamin A D and enough exercise. (Active, healthy, younger dogs are said to do better with the treatment, but older, less active dogs have done well also.)
February 14th 2013 3:11 pm
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Dogster is not working well for us, but trying to resolve too.
cannot send PPRs, gifts etc.. We wanted to wish everyone a YAPPY day and say TY to every pup who sent greetings & treats. We love you right back!
m, m & angel m, as the purple girls of oregon
January 21st 2013 12:45 am
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Posted here is a url link to my Facebook page.
Here is why..
Just saw someone dump an absolutely lovely 8 yr old Blind Siberian Husky in a CA shelter. He is reposted on our Facebook page.. First saw the kind link made by a fellow friend & Dogster favorite Teresa Hicks, Angel KISKA'S, and of KJ & Rain's mom.. I have Always known the HUSKY lovers around here to be some of the most loyal, loving, big hearted folks we have ever met..
Does AnYoNe know of a Sibe Rescue Group in CA that can help this fella?
The Baldwin Shelter is where he is. More info available through that link!
We see and speak out against animal neglect and cruelty, recommend adoption, spay & neutering but as you know our main emphasis is to help fund a cure for IMHA. For more informtion PAWlease see ecollage.org
Regarding Mica's IMHA Research & Fund
And her & Mirra's advocacy work... We can use all the hlp we can get. We are dying FUR a cure.
There are lost dogs, which we ALWAYS advocate for, but as you know we cannot do it all, just like no one person can. But if anyone can help this handsome lad, I just feel that we are in it with Mirra FUR as long as we can get with her..
How can someone just dump off an 8 yr old blind dog like this and sleep at night? Its not my dog, and evidently I am losing sleep over this.
We work with Belgian Tervuren Rescue, and Belgian Groendael Rescue closely. We have advocated for Newfoundland Rescue and helped others. There must be a Siberian Rescue out there, that might know a placement for him, or help find him a good home. Won't someone come take a look or contact us here or though Mica's Foundation at ecollage.org
Or on Facebook? PAWlease? Thanks FUR hearing us BOL!
This saddens me, and makes me mad as hell at the same time.
This is a defenseless and blameless animal, once again a victim of some selfish individual out there. If we can be of further help, please contact us.
January 9th 2012 1:52 pm
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My sister Sufi is with Angel mica now. PAWlease pray for her mom, Loa. Sufi developed complications Saturday night which caused severe neurological difficulties. she was humanely euthanized which was a hard decision FUR her mom, but she never wanted her to suffer. It will be very hard for her to live without her best friend. Our hearts are breaking FUR this family, and this loss is PAWticularly hard.
rest in peace little one..
30 May 2007-7 January 2012
January 1st 2012 1:50 pm
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Pawlease, furiends.. Pawray FUR my sister, SUFI, who was just diagnosed after Christmas with IMHA. She is being treated in the San Francisco Bay area, and her mom is beside herself with worry.
Her current pvc is 17.. Poor Sufi is one sick dog.
we really do need a cure, because they still don't know what triggered it... Like so many we hear from this news hit us terribly hard.
Thank you FUR your pawrayers too mates.. We all need them. Pawlease know tht we have our loved ones in ours too.
May we all have good health in the New Year.
Mirra, mel & Angel Mica
May 29th 2011 10:00 pm
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i'll be 4 on 30 MAY 2011.. PAWlease, come wish me well, then get involved to try and YELP!!-help other dogs find LOVING HOMES, as I am so lucky, but also PAWlease, don't FURget about my ANGEL mica, and her quest FUR a cure 4 IMHA..
and help us .. even a dollar-at-a-time makes a difference. you may not think so, but dollars do ADD UP when put together!!
mirra & mel
thanks to all of our LOVED ones, who help make a difference..
October 18th 2010 6:10 pm
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Mirra has done well in everything then recently emerged on Columbus Day with acute pancreatitis.. we cannot tell if it may be the Grizzly Salmon Oil, which we no longer use, The Orijen, which may be too high in Protein, or the small amount of EVO 95% protein, which actually has 9% protein and same for fat.
She's recuperating well, Thank the Lord, on home-cooked- the type you may imagine, but other than an abysmal vet prescribed diet- has anyone found a good lower protein, very low fat food that has reliable analysis (what they call dry matter basis?)
I love her with my whole heart, and other than lowfat yogurt, same for cottage cheese, carrots, bananas and lettuce- she occasionally gets a tiny bit of cheese, and baked liver- which i make as well, for treats. i want to do the right thing, and i am not looking for criticism, if it is choices i have made that led to this i feel bad enough already, i just would appreciate guidance if anyone is willing to bestow it in the kind manner i ask for it in, and thank you. it's a terrible thing, hearing your pup has acute pancreatitis..
i'm sure many of you know all too well.
mirra is doing well, but i want her to do great.
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