Is Heartguard safe for border collies? I've read conflicting reports.
my dog was diagnosed with class 1 heartworm. he is asymptomatic. he was prescribed heartguard monthly for minimum of 1yr. i gave him his first dose today and he has spent most of the day sleeping. he has exercised for a few minutes but tires easily, within 15 mins and immediately lies down and goes to sleep. is this normal? should i be worried?
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When it comes to herding breeds and many sighthounds, owners need to be very careful when administering heartworm/fea/tick preventatives or treatments. Many herding and sighthound breeds or mixed dogs with those breeds have a genetic mutation in the MDR-1 gene that renders them very susceptible to Ivermectin (Ivermec), the primary ingredient in Heartgard.
Drugs that cause reaction to MDR-1 mutant dogs include:
- Acepromazine (tranquilizer):
- Butorphanol (pain control);
- Cyclosporin (immunosuppression drug);
- Digoxin (heart drug);
- Doxorubicin (anticancer drug);
- Ivermectin (antiparasitic drug);
- Loperamide (Imodium®, antidiarrheal drug);
- Vinblastine (anticancer drug);
- Vincristine (anticancer drug)
Symptoms can range from lethargy and poor coordination to coma and death.
Genetic tests are available to determine if your dog has the mutant form of MDR-1.
Gio answered on 8/1/08. Helpful? / 3
I agree with the last poster and can't believe your Dr would give you Heartgard. It is KNOWN not to be safe in shelties, collies, and border collies (among a few other breeds).. It's not to say that every case is going to turn out the same but I wouldn't give him any more to be on the safe side. I might find a different vet...sounds as if you may be playing with fire. You definitely don't want to take any chances!
Lennox answered on 8/1/08. Helpful? / 1